INT218004

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.37
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cd1d1) histone binding (Cd1d1) plasma membrane (Cd1d1)
lysosome (Cd1d1) cytoplasm (Cd1d1)
Cd1d1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 2 60.76 Quite High
addiction 12 53.76 Quite High
Migraine 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 46 91.76 High High
Shock 8 65.68 Quite High
Body Weight 40 5.00 Very Low Very Low Very Low
Channelopathies 16 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Migraine With Aura 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For CDI, there are potential indications that CDI may be affected by mutating the selectivity filter or substituting the permeant ion (Zong et al., 1994; Babich et al., 2005, 2007), motivating the notion that CDI might be linked to selectivity filter rearrangements.
Regulation (affected) of CDI
1) Confidence 0.44 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0.07 Pain Relevance 0
Second, CDImax is the fractional change in open probability of the normal mode (PO-PEAK in Eq. 2) versus the inactivated mode (PO-INACTIVATED = QEFF · b(V) · L · a · f/(1 + QEFF · b(V) · L · a · f)).
Regulation (change) of CDI
2) Confidence 0.26 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2828906 Disease Relevance 0 Pain Relevance 0.03
Furthermore, our results show that the S-D rat is less sensitive to dietary phytoestrogens than either the CD-1 mouse or the F344 rat.
Regulation (sensitive) of CD-1
3) Confidence 0.03 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137112 Disease Relevance 0.22 Pain Relevance 0.03
We conclude that a) the CD-1 mouse and the F344 rat are considerably more sensitive to dietary phytoestrogens than the S-D rat; b) the same diet milled on different dates may have significantly different phytoestrogen content, which will cause marked differences in the time of VO in CD-1 mice and F344 rats, but less so in S-D rats; c) variations in the phytoestrogen content of rodent diets could be overcome by using soy- and alfalfa-free diets and by eliminating other known sources of estrogens; and d) a standardized open-formula phytoestrogen-deficient diet (one essentially devoid of known phytoestrogens) providing approximately 3.1 Kcal/g diet of ME, coupled with a more estrogen-sensitive rodent model (e.g., CD-1 mice, F344 rats) would be most appropriate to use in bioassays for evaluating the estrogenic activity of EDCs.



Regulation (sensitive) of CD-1
4) Confidence 0.02 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137112 Disease Relevance 0.09 Pain Relevance 0

General Comments

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