INT218011

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AHR, CYP27B1) mitochondrion (CYP27B1) immune system process (AHR)
small molecule metabolic process (CYP27B1) cell morphogenesis (AHR) DNA binding (AHR)
AHR (Homo sapiens)
CYP27B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 81.00 Quite High
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 43.24 Quite Low
Body Weight 3 5.00 Very Low Very Low Very Low
Lymphopenia 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Disease Susceptibility 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Feminization 1 5.00 Very Low Very Low Very Low
Nephrotoxicity 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fish, this effect is mediated through an estrogen receptor–dependent mechanism (Navas and Segner 2001), as is the case in mammals where estrogens decrease cyp1a expression by altering recruitment of the transcription factor nuclear factor-1 to the AhR, a process that normally increases cyp1a transcription (Ricci et al. 1999).
AhR Positive_regulation (increases) of Transcription (transcription) of cyp1a
1) Confidence 0.16 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0 Pain Relevance 0.04

General Comments

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