INT218018

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.74
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peroxisome (GSTK1) intracellular (GSTK1)
GSTK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 3 94.84 High High
agonist 2 68.24 Quite High
Paracetamol 2 32.40 Quite Low
Potency 4 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 56 99.80 Very High Very High Very High
Nicotine Addiction 78 99.52 Very High Very High Very High
Stress 29 96.88 Very High Very High Very High
Disease Susceptibility 4 96.00 Very High Very High Very High
Aging 5 74.24 Quite High
Cancer 24 73.36 Quite High
Myocardial Infarction 1 52.64 Quite High
Disease 22 42.24 Quite Low
Increased Venous Pressure Under Development 7 42.08 Quite Low
Toxicity 7 36.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As mentioned above, there are still some controversies about the relationship between GST polymorphism and CAD in smokers.
Regulation (controversies) of Gene_expression (polymorphism) of GST associated with nicotine addiction and coronary artery disease
1) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 1.99 Pain Relevance 0
Why, then, do GST polymorphisms apparently have less impact on pharmacokinetics?
Regulation (have) of Gene_expression (polymorphisms) of GST
2) Confidence 0.29 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.07 Pain Relevance 0
The lack of treatment effects on gst expression in females may relate to their higher levels of endogenous estrogen that, in turn, are likely to account for the lower gst levels observed in females compared with males, and may render them less sensitive to induction/inhibition by exogenous chemicals.
Regulation (effects) of Gene_expression (expression) of gst
3) Confidence 0.19 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.08 Pain Relevance 0.03
As for the genotoxic effects, however, the strong inhibitory effect of the weakly estrogenic effluent alone (without EE2) on gst levels in males suggests that other chemicals present in the effluent may have also contributed to this observed response.
Regulation (effect) of Gene_expression (levels) of gst
4) Confidence 0.16 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.09 Pain Relevance 0.03
We also present evidence that the transcription factor SKN-1 is involved in regulating the GST expression induced by AITC.


Regulation (regulating) of Gene_expression (expression) of GST
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2822842 Disease Relevance 0.51 Pain Relevance 0.05

General Comments

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