INT21805

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Context Info
Confidence 0.30
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 9.66
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hdlbp) RNA binding (Hdlbp) nucleus (Hdlbp)
cytoplasm (Hdlbp)
Anatomy Link Frequency
blood 2
plasma 1
Hdlbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
psoriasis 145 98.96 Very High Very High Very High
Paracetamol 8 98.40 Very High Very High Very High
Arthritis 15 97.44 Very High Very High Very High
Inflammation 58 87.60 High High
Serotonin 1 87.44 High High
antagonist 1 85.92 High High
ischemia 1 77.40 Quite High
Glutamate 1 76.80 Quite High
Analgesic 2 73.72 Quite High
Angina 2 67.44 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 56 100.00 Very High Very High Very High
Hyperlipidemia 13 99.90 Very High Very High Very High
Atherosclerosis 20 99.66 Very High Very High Very High
Hyperglycemia 7 99.46 Very High Very High Very High
Abdominal Obesity 2 99.00 Very High Very High Very High
Psoriasis 156 98.96 Very High Very High Very High
Congenital Anomalies 8 98.96 Very High Very High Very High
Pressure And Volume Under Development 59 98.66 Very High Very High Very High
Diabetes Mellitus 106 98.60 Very High Very High Very High
Seronegative Spondarthritis 10 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under in vivo experiment, BS extract significantly reduced serum total cholesterol (38-48 %), increased serum high-density lipoprotein- cholesterol (HDL-cholesterol, 22-30%).
Negative_regulation (reduced) of high-density lipoprotein associated with disorder of lipid metabolism
1) Confidence 0.30 Published 2005 Journal Indian J. Exp. Biol. Section Abstract Doc Link 15991575 Disease Relevance 0.35 Pain Relevance 0.15
Paracetamol overdose caused significant (p<0.05) increase in the plasma Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Blood Urea Nitrogen (BUN), triglycerides (TAG) with total cholesterol (TC) and Low Density Lipoprotein (LDL-cholesterol) and significant (p<0.05) decrease Total Protein (TP) and High Density Lipoprotein (HDL-cholesterol) in rats treated with paracetamol alone when compared with rats pre-treated with extract of Cnidoscolus aconitifolius.
Negative_regulation (decrease) of High Density Lipoprotein in Blood associated with paracetamol, disorder of lipid metabolism and overdose
2) Confidence 0.16 Published 2010 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 20437682 Disease Relevance 0.51 Pain Relevance 0.61
The most common lipid abnormalities in these patients include hypertriglyceridemia and reduced high-density lipoprotein (HDL) cholesterol levels.
Negative_regulation (reduced) of high-density lipoprotein associated with congenital anomalies, hyperlipidemia and disorder of lipid metabolism
3) Confidence 0.14 Published 2010 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2859276 Disease Relevance 2.17 Pain Relevance 0
The results show that there were significant (P < 0.05) increases in total serum cholesterol, triglyceride and low-density lipoprotein cholesterol (LDL-C) and a decrease in high-density lipoprotein cholesterol (HDL-C) in streptozotocin-induced diabetic rats.
Negative_regulation (decrease) of high-density lipoprotein cholesterol associated with diabetes mellitus and disorder of lipid metabolism
4) Confidence 0.12 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2898543 Disease Relevance 0.83 Pain Relevance 0
Metabolic Syndrome (MS) is defined as the presence of at least three of the following changes: blood hypertension, central obesity, fasting hyperglycemia, hypertriglyceridemia and reduced high density lipoprotein (HDL) [18].
Negative_regulation (reduced) of high density lipoprotein in blood associated with hyperglycemia, pressure and volume under development, abdominal obesity, metabolic syndrome, hyperlipidemia and disorder of lipid metabolism
5) Confidence 0.08 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2262079 Disease Relevance 2.78 Pain Relevance 0.17
Furthermore, patients with psoriasis appear to be at increased risk of atherosclerosis, which may at least in part be explained by an abnormal plasma lipid metabolism; serum lipoprotein (a) and triglycerides are significantly increased in patients with psoriasis compared with healthy control subjects [73], while high-density lipoprotein (HDL) cholesterol is significantly decreased [60].
Negative_regulation (decreased) of high-density lipoprotein in plasma associated with psoriasis, atherosclerosis and disorder of lipid metabolism
6) Confidence 0.03 Published 2006 Journal Arch Dermatol Res Section Body Doc Link PMC1705513 Disease Relevance 1.86 Pain Relevance 0.31
Measurements aimed at reversing the process of atherosclerosis via cholesterol reduction and enhanced high density lipoprotein activity are encouraging.
Negative_regulation (reduction) of high density lipoprotein associated with atherosclerosis
7) Confidence 0.02 Published 1990 Journal Circulation Section Abstract Doc Link 2203564 Disease Relevance 1.01 Pain Relevance 0.19

General Comments

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