INT21806

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.16
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hdlbp) RNA binding (Hdlbp) nucleus (Hdlbp)
cytoplasm (Hdlbp)
Anatomy Link Frequency
kidney 1
Hdlbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 3 92.80 High High
nud 1 87.84 High High
Serotonin 1 87.44 High High
antagonist 1 85.92 High High
alcohol 9 81.60 Quite High
ischemia 1 76.84 Quite High
Glutamate 6 76.80 Quite High
Analgesic 1 72.00 Quite High
Inflammation 10 71.96 Quite High
Angina 3 66.88 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 41 100.00 Very High Very High Very High
Insulin Resistance 18 99.96 Very High Very High Very High
Atherosclerosis 40 99.38 Very High Very High Very High
Polyps 1 99.24 Very High Very High Very High
Pressure And Volume Under Development 4 98.18 Very High Very High Very High
Endometriosis (extended) 11 97.86 Very High Very High Very High
Cardiovascular Disease 28 97.58 Very High Very High Very High
Hypertension 43 97.28 Very High Very High Very High
Diabetes Mellitus 13 97.04 Very High Very High Very High
Recurrence 4 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under in vivo experiment, BS extract significantly reduced serum total cholesterol (38-48 %), increased serum high-density lipoprotein- cholesterol (HDL-cholesterol, 22-30%).
Positive_regulation (increased) of high-density lipoprotein associated with disorder of lipid metabolism
1) Confidence 0.49 Published 2005 Journal Indian J. Exp. Biol. Section Abstract Doc Link 15991575 Disease Relevance 0.34 Pain Relevance 0.15
For example, calcium may play a role in increasing levels of high-density lipoprotein, preventing colon polyp formation, reducing blood pressure in some hypertensive individuals, reducing kidney stone recurrence, promoting weight loss, and reducing the symptoms of premenstrual syndrome.
Positive_regulation (increasing) of high-density lipoprotein in kidney associated with weight loss, hypertension, dismenorea, polyps, kidney stones and recurrence
2) Confidence 0.44 Published 2003 Journal Urol Nurs Section Abstract Doc Link 12677721 Disease Relevance 0.92 Pain Relevance 0.09
At day 14, spectra from rats exposed to PB demonstrated a shift in the terminal methyl lipoprotein resonance to a lower chemical shift reflecting an increase in high density lipoprotein and decrease in low density lipoprotein as has been reported in PB-exposed Sprague Dawley rats [29].


Positive_regulation (increase) of high density lipoprotein
3) Confidence 0.10 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0.03
In addition, during menopause, women experience adverse changes in cardiovascular risk factors, including declines in concentrations of high-density lipoprotein (HDL) cholesterol and increases in concentrations of total cholesterol, LDL cholesterol, HDL3 cholesterol, and triglycerides [65, 66].
Positive_regulation (increases) of high-density lipoprotein associated with endometriosis (extended) and disorder of lipid metabolism
4) Confidence 0.06 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001222 Disease Relevance 0.67 Pain Relevance 0
Many positive benefits have been associated with diets rich in fiber, including a reduced risk of diabetes and cardiovascular disease, reduced risk of hypertension, as well as a reduction of total and low density lipoprotein (LDL) cholesterol [2] and an increase in high density lipoprotein (HDL) cholesterol [3-6].
Positive_regulation (increase) of high density lipoprotein associated with pressure and volume under development, cardiovascular disease, diabetes mellitus and disorder of lipid metabolism
5) Confidence 0.05 Published 2009 Journal Nutr J Section Body Doc Link PMC2633017 Disease Relevance 0.56 Pain Relevance 0.04
Measurements aimed at reversing the process of atherosclerosis via cholesterol reduction and enhanced high density lipoprotein activity are encouraging.
Positive_regulation (enhanced) of high density lipoprotein associated with atherosclerosis
6) Confidence 0.03 Published 1990 Journal Circulation Section Abstract Doc Link 2203564 Disease Relevance 1.01 Pain Relevance 0.19
Low ethanol improves insulin resistance, increases high-density lipoprotein and stimulates activity of the antioxidant enzyme, paraoxonase.
Positive_regulation (increases) of high-density lipoprotein associated with insulin resistance
7) Confidence 0.02 Published 2006 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC1993980 Disease Relevance 0.66 Pain Relevance 0.08

General Comments

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