INT21813

Context Info Confidence 0.61 First Reported 1980 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 10 Total Number 10 Disease Relevance 3.68 Pain Relevance 1.81

lipid binding (Apoa2) protein folding (Apoa2) transport (Apoa2) extracellular space (Apoa2) extracellular region (Apoa2) cellular_component (Apoa2)

Anatomy Link Frequency plasma 1 ventricle 1 cardiovascular system 1 CER 1 Apoa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat electroacupuncture 7 99.20 substance P 2 98.08 Cholecystokinin 2 97.30 tolerance 3 96.76 Angina 2 96.12 antinociception 5 92.76 tail-flick 3 87.44 tetrodotoxin 1 86.72 Kinase C 10 86.04 antagonist 8 85.04

Disease Link Frequency Relevance Heat Coronary Stenosis 10 99.72 Disorder Of Lipid Metabolism 14 99.66 Wound Healing 2 98.60 Cv General 3 Under Development 5 96.12 Stress 17 94.28 Increased Venous Pressure Under Development 27 89.80 Injury 12 87.80 Diabetes Mellitus 50 87.44 Malignant Neoplastic Disease 2 80.24 Renal Disease 4 79.60

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The results suggest that the acceleration of the synthesis and release of AII during a long-term EA stimulation might constitute one of the mechanisms for EA tolerance.

Gene_expression (synthesis) of AII associated with tolerance and electroacupuncture

1) Confidence 0.61 Published 1990 Journal Sci. China, Ser. B, Chem. Life Sci. Earth Sci. Section Abstract Doc Link 2204346 Disease Relevance 0 Pain Relevance 0.49

These results suggest that an immediate and transient reduction in AII receptor expression occurred after wounding, followed by an increase in the number of AII receptors that was maintained for 5 to 7 days postoperatively.

Gene_expression (expression) of AII receptor

2) Confidence 0.43 Published 1996 Journal J Invest Surg Section Abstract Doc Link 8981218 Disease Relevance 0.46 Pain Relevance 0.08

Because these data are consistent with those observed after excisional wounding, temporal changes in AII receptor expression may be integral to the process of wound healing.

Gene_expression (expression) of AII receptor associated with wound healing

3) Confidence 0.43 Published 1996 Journal J Invest Surg Section Abstract Doc Link 8981218 Disease Relevance 0.51 Pain Relevance 0.07

In the rat, the species in which the physiological mechanisms of thirst have been most thoroughly studied, the levels of circulating AII produced by systemic administration of dipsogenic doses of the octapeptide have not been established.

Gene_expression (produced) of AII

4) Confidence 0.41 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0.17 Pain Relevance 0

In the present series of investigations, plasma levels of AII were determined following infusions of the peptide over a range of doses frequently employed in studies on thirst.

Gene_expression (levels) of AII in plasma

5) Confidence 0.32 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0.24 Pain Relevance 0

Our results suggest that both AII and AIII produced a reduction, via AT2 receptors, of the activity of alpha-2 adrenoceptors in the NRGC that are involved in central cardiovascular regulation.

Gene_expression (produced) of AII

6) Confidence 0.31 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8930186 Disease Relevance 0.13 Pain Relevance 0.56

We examined the association of cholesterol levels in serum lipoprotein fractions, as well as of serum apolipoprotein-AI (apo-AI) and apo-AII levels, with coronary artery stenosis (CAS) and left ventricle function in a group of 43 patients with angina pectoris (33 men and 10 women) subjected to angiography.

Gene_expression (levels) of apo-AII in ventricle associated with coronary stenosis, angina and disorder of lipid metabolism

7) Confidence 0.04 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3098880 Disease Relevance 0.73 Pain Relevance 0.10

In these effects an activated ET is likely to mediate the activity of the AII through NOX activation as AII-evoked expression of ET-1 in adventitial fibroblasts appears to be mediated, at least in part, by NOX.66 The mitochondrial ROS is responsible to mediate the activity of ET-1 in the cardiovascular system.67 The vascular activity of AII is closely related to ET-1, coronary vasoconstriction by ?

Gene_expression (expression) of AII-evoked in cardiovascular system associated with increased venous pressure under development

8) Confidence 0.03 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.70 Pain Relevance 0.15

The isolated, spontaneously active portal vein of guinea pig was stimulated by the following compounds (the pD2 is given in parentheses): caerulein (CER, 8.02), cholecystokinin octapeptide (CCK-8, 7.59), substance P (SP, 4.68), and carbachol (5.37), whereas neurotensin (NT) was ineffective and angiotensin II (AII) produced inhibition.

Gene_expression (produced) of AII in CER associated with cholecystokinin and substance p

9) Confidence 0.02 Published 1987 Journal Pharmacology Section Abstract Doc Link 2437599 Disease Relevance 0 Pain Relevance 0.26

They have also shown that pioglitazone increases apoA-II synthesis and mRNA expression in HepG2 cells.

Gene_expression (synthesis) of apoA-II

10) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2729049 Disease Relevance 0.73 Pain Relevance 0.10

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