INT21817

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.88
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Thop1) cytoplasm (Thop1)
Anatomy Link Frequency
plasma 3
brain 2
cleavage 1
Thop1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 18 99.96 Very High Very High Very High
Dynorphin 16 99.76 Very High Very High Very High
Enkephalin 23 99.60 Very High Very High Very High
medulla 2 98.40 Very High Very High Very High
Spinal cord 3 97.40 Very High Very High Very High
nociceptor 6 97.08 Very High Very High Very High
Pain 6 95.60 Very High Very High Very High
Inflammation 4 91.72 High High
Neuropeptide 8 89.84 High High
ischemia 1 89.56 High High
Disease Link Frequency Relevance Heat
Pain 2 95.60 Very High Very High Very High
INFLAMMATION 4 91.72 High High
Cv Unclassified Under Development 1 89.56 High High
Cognitive Disorder 3 88.88 High High
Nociception 4 84.08 Quite High
Birth Weight 6 55.20 Quite High
Pulmonary Disease 1 54.24 Quite High
Schizophrenia 9 54.08 Quite High
Premature Birth 1 26.40 Quite Low
Reprotox - General 2 1 25.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A polyclonal antibody exhibiting high affinity for endo-oligopeptidase was raised in rabbits against the purified rat brain enzyme and used to localize endo-oligopeptidase by Western blotting and by immunoperoxidase techniques.
endo-oligopeptidase Binding (affinity) of in brain
1) Confidence 0.48 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2204681 Disease Relevance 0 Pain Relevance 0.31
Brain contains a membrane-bound form of endopeptidase-24.15, a metalloendopeptidase predominantly associated with the soluble protein fraction of brain homogenates.
endopeptidase-24.15 Binding (associated) of in brain
2) Confidence 0.26 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 2878974 Disease Relevance 0 Pain Relevance 0.25
These data suggest that DABF functions as an oligopeptidase that forms stable and specific complexes with dynorphin A.
oligopeptidase Binding (complexes) of associated with dynorphin
3) Confidence 0.25 Published 2004 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15358236 Disease Relevance 0 Pain Relevance 1.16
Met-enkephalin-Arg6-Phe7 (E7) is converted to Met-enkephalin by rat striatal membranes; in contrast, Leu-enkephalin (E5) is inactivated by cleavage at the Tyr-Gly (aminopeptidase) and Gly-Phe sites (metalloendopeptidase).
metalloendopeptidase Binding (cleavage) of in cleavage associated with enkephalin
4) Confidence 0.21 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154837 Disease Relevance 0 Pain Relevance 0.74
Among the various enzymes tested, the angiotensin-converting enzyme, the thermolysin-like metalloendopeptidase ('enkephalinase'), a thyroliberin-degrading enzyme and some aminopeptidasic activities were found to be associated with the plasma membrane.
metalloendopeptidase Binding (associated) of in plasma
5) Confidence 0.19 Published 1984 Journal Eur. J. Biochem. Section Abstract Doc Link 6199201 Disease Relevance 0 Pain Relevance 0.33
Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme.
metalloendopeptidase Binding (interaction) of
6) Confidence 0.15 Published 1984 Journal Eur. J. Biochem. Section Title Doc Link 6321177 Disease Relevance 0 Pain Relevance 0.12
Among several metalloendopeptidases that metabolize and inactivate BK, EP24.15 and EP24.16 are known to associate with the plasma membrane in several immortalized cell lines.
EP24 Binding (associate) of in plasma associated with bradykinin
7) Confidence 0.03 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.27 Pain Relevance 0.61
Among several metalloendopeptidases that metabolize and inactivate BK, EP24.15 and EP24.16 are known to associate with the plasma membrane in several immortalized cell lines.
EP24 Binding (associate) of in plasma associated with bradykinin
8) Confidence 0.03 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16515556 Disease Relevance 0.27 Pain Relevance 0.62
This causes THOP which is more intense and prolonged when more premature the birth (van Wassenaer and Kok 2008).
THOP Binding (intense) of
9) Confidence 0.02 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.34 Pain Relevance 0.04

General Comments

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