INT21822

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 1990
Negated 3
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1A1) small molecule metabolic process (SULT1A1) cytoplasm (SULT1A1)
Anatomy Link Frequency
platelets 3
neurons 1
SULT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 1 99.98 Very High Very High Very High
Neurotransmitter 3 95.40 Very High Very High Very High
Paracetamol 43 93.88 High High
Dopamine 1 87.32 High High
monoamine 1 86.20 High High
medulla 1 81.52 Quite High
Raphe 1 76.32 Quite High
cerebral cortex 1 57.00 Quite High
Catecholamine 1 54.08 Quite High
Enkephalin 1 47.36 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phenol sulfotransferase in humans: properties, regulation, and function.
Regulation (regulation) of Phenol sulfotransferase
1) Confidence 0.62 Published 1986 Journal Fed. Proc. Section Title Doc Link 2873064 Disease Relevance 0 Pain Relevance 0.16
Human platelets contain two independently regulated forms of the drug conjugating enzyme, phenol sulfotransferase (PST).
Neg (independently) Regulation (regulated) of phenol sulfotransferase in platelets
2) Confidence 0.45 Published 1982 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6957279 Disease Relevance 0 Pain Relevance 0.24
Human platelets contain two independently regulated forms of the drug conjugating enzyme, phenol sulfotransferase (PST).
Neg (independently) Regulation (regulated) of PST in platelets
3) Confidence 0.27 Published 1982 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6957279 Disease Relevance 0 Pain Relevance 0.24
There was no significant correlation between the independently regulated activities of the TS and TL forms of PST in the platelets of these subjects (r = 0.16, P less than 0.4).
Neg (independently) Regulation (regulated) of PST in platelets
4) Confidence 0.27 Published 1982 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 6957279 Disease Relevance 0 Pain Relevance 0.89
In the hippocampus PST immunoreactivity was localized in both the pyramidal and nonpyramidal neurons and was in greatest abundance in the CA2 and CA3 areas.
Regulation (immunoreactivity) of PST in neurons associated with hippocampus
5) Confidence 0.27 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2204682 Disease Relevance 0 Pain Relevance 0.22

General Comments

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