INT21825

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Context Info
Confidence 0.05
First Reported 1990
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.05
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Alpk1) kinase activity (Alpk1) cellular_component (Alpk1)
biological_process (Alpk1)
Alpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 2 86.88 High High
cytokine 1 86.72 High High
abdominal pain 2 71.88 Quite High
Disease Link Frequency Relevance Heat
Toxicity 4 98.68 Very High Very High Very High
Renal Cancer 4 97.68 Very High Very High Very High
Pressure And Volume Under Development 4 97.48 Very High Very High Very High
Pressure Volume 2 Under Development 1 89.80 High High
Exanthema 1 89.12 High High
Vomiting 6 87.96 High High
Fatigue 1 87.24 High High
Headache 2 86.88 High High
Myalgia 1 86.48 High High
Chills 2 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LAK activity could be enhanced if rIL-2 was present during the 4-h assay.
Positive_regulation (enhanced) of LAK
1) Confidence 0.05 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2205379 Disease Relevance 0.07 Pain Relevance 0
The induction and persistence of LAK activity were studied.
Positive_regulation (induction) of LAK
2) Confidence 0.05 Published 1990 Journal Cancer Res. Section Abstract Doc Link 2205379 Disease Relevance 0.91 Pain Relevance 0.07
Whereas natural killer (NK) or LAK activity or both were significantly increased in four of eight patients studied, only one patient with renal cell cancer had a minor response for four treatment cycles.
Positive_regulation (increased) of LAK associated with renal cancer
3) Confidence 0.05 Published 1997 Journal J. Immunother. Section Abstract Doc Link 9101417 Disease Relevance 1.31 Pain Relevance 0.13
It was suggested that the clinical response would be expected in case of increasing of CD16 cells or CD25 cells and augmentation of NK or LAK activity.
Positive_regulation (augmentation) of LAK
4) Confidence 0.03 Published 1993 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8320888 Disease Relevance 0.75 Pain Relevance 0.08

General Comments

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