INT218260

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP) extracellular region (CRP)
CRP (Homo sapiens)
HIST2H4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 65 39.00 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammatory marker 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 65 99.82 Very High Very High Very High
Coronary Artery Disease 185 98.48 Very High Very High Very High
INFLAMMATION 65 39.00 Quite Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low
Nicotine Addiction 20 5.00 Very Low Very Low Very Low
Death 15 5.00 Very Low Very Low Very Low
Atherosclerosis 15 5.00 Very Low Very Low Very Low
Obesity 10 5.00 Very Low Very Low Very Low
Vasculitis 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Though the Rotterdam Study did not genotype 2667G>C, they reported four haplotypes significantly associated with CRP levels, and reported no associations with CHD.[22] A recent study in the Cardiovascular Health Study of older adults reported no association between five CRP haplotypes and risk of MI among white participants, and the relative risk of MI for our H4 equivalent was 0.93 (95% CI 0.72–1.21).[24] On the other hand, though H4 was not associated with CRP levels in the Physicians' Health Study, 3872C>T individually was associated with lower CRP levels, and with an increased risk of MI (odds ratio: 1.29, 95% CI 0.99–1.67).[23] Furthermore, the odds ratio for 2667G>C was suggestive of a 50% increase as well, but the confidence interval was much wider.
CRP Binding (associated) of H4 associated with coronary artery disease and myocardial infarction
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.53 Pain Relevance 0
Though the Rotterdam Study did not genotype 2667G>C, they reported four haplotypes significantly associated with CRP levels, and reported no associations with CHD.[22] A recent study in the Cardiovascular Health Study of older adults reported no association between five CRP haplotypes and risk of MI among white participants, and the relative risk of MI for our H4 equivalent was 0.93 (95% CI 0.72–1.21).[24] On the other hand, though H4 was not associated with CRP levels in the Physicians' Health Study, 3872C>T individually was associated with lower CRP levels, and with an increased risk of MI (odds ratio: 1.29, 95% CI 0.99–1.67).[23] Furthermore, the odds ratio for 2667G>C was suggestive of a 50% increase as well, but the confidence interval was much wider.
CRP Binding (associated) of H4 associated with coronary artery disease and myocardial infarction
2) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.54 Pain Relevance 0
Compared to H1, H3 and H4 were associated with 24–44% lower CRP levels among both men and women, and these findings were as expected from their individual variant alleles.
CRP Binding (associated) of H4
3) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.28 Pain Relevance 0
Several studies have shown H4 as associated with significantly lower CRP levels.[9], [16], [23], [24], [32] However, specifically of importance, few studies have assessed haplotypes, and H4 in particular, with risk of incident CHD.
CRP Binding (associated) of H4 associated with coronary artery disease
4) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.31 Pain Relevance 0
Several studies have shown H4 as associated with significantly lower CRP levels.[9], [16], [23], [24], [32] However, specifically of importance, few studies have assessed haplotypes, and H4 in particular, with risk of incident CHD.
CRP Binding (associated) of H4 associated with coronary artery disease
5) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148071 Disease Relevance 0.28 Pain Relevance 0

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