INT218287

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.51
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fbxo32)
Anatomy Link Frequency
muscle 1
head 1
Fbxo32 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 86.32 High High
Inflammation 14 71.52 Quite High
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscular Atrophy 15 98.64 Very High Very High Very High
Insulin Resistance 9 85.60 High High
INFLAMMATION 17 71.52 Quite High
Necrosis 1 70.00 Quite High
Cancer 5 69.64 Quite High
Frailty 57 50.00 Quite Low
Chronic Renal Failure 28 50.00 Quite Low
Stress 25 49.92 Quite Low
Acidosis 6 41.84 Quite Low
Hypertrophy 4 38.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DETA-NO resulted in a moderate, but significant, reduction in the basal level expression MAFbx/atrogin-1 mRNA and completely blocked the induction of MAFbx/atrogin-1 induced by TNF-?
Positive_regulation (induction) of atrogin-1
1) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0 Pain Relevance 0.04
DETA-NO resulted in a moderate, but significant, reduction in the basal level expression MAFbx/atrogin-1 mRNA and completely blocked the induction of MAFbx/atrogin-1 induced by TNF-?
Positive_regulation (induction) of MAFbx
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361191 Disease Relevance 0 Pain Relevance 0.04
Atrogin-1 is upregulated under conditions associated with muscle atrophy [48].
Positive_regulation (upregulated) of Atrogin-1 in muscle associated with muscular atrophy
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.10 Pain Relevance 0
The activation of atrogin-1, and hence the UPS, involves another mechanism: changes in activity of the fork-head transcription factors (FoxO 1, 3 and 4).
Positive_regulation (activation) of atrogin-1 in head
4) Confidence 0.14 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.42 Pain Relevance 0.13

General Comments

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