INT218293

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 14
Total Number 20
Disease Relevance 4.22
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Acvr2b) plasma membrane (Acvr2b) kinase activity (Acvr2b)
cytoplasm (Acvr2b)
Anatomy Link Frequency
muscle 6
skeletal muscle 2
quadriceps 1
hearts 1
microglia 1
Acvr2b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 150 96.12 Very High Very High Very High
anesthesia 18 91.44 High High
Intracerebroventricular 8 80.80 Quite High
Hippocampus 70 5.00 Very Low Very Low Very Low
cINOD 52 5.00 Very Low Very Low Very Low
Central nervous system 42 5.00 Very Low Very Low Very Low
cytokine 28 5.00 Very Low Very Low Very Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
ketamine 17 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 115 100.00 Very High Very High Very High
Hypertrophy 124 99.40 Very High Very High Very High
Coronary Heart Disease 20 98.96 Very High Very High Very High
INFLAMMATION 178 96.12 Very High Very High Very High
Disease 34 85.12 High High
Dilated Cardiomyopathy 25 78.20 Quite High
Hyperinsulinism 13 76.48 Quite High
Body Weight 30 72.96 Quite High
Lifespan 10 58.96 Quite High
Neurodegenerative Disease 256 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not known whether the polymorphisms in the ACVR2B genes in the different haplotypes affect ACVR2B expression in muscle.
Gene_expression (expression) of ACVR2B in muscle
1) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.26 Pain Relevance 0
Two of the genes expressed at higher levels in women, GRB10 and ACVR2B, encode proteins that are in signaling pathways of growth factors known to regulate muscle mass.
Gene_expression (expressed) of ACVR2B in muscle
2) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.08 Pain Relevance 0
Because testosterone is assumed to be responsible for the greater muscle mass in men, an obvious issue is whether it regulates expression of GRB10 or ACVR2B genes.
Gene_expression (expression) of ACVR2B in muscle
3) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.24 Pain Relevance 0
Quantitative RT-PCR confirmed higher expression of GRB10 and ACVR2B genes in these women.
Gene_expression (expression) of ACVR2B
4) Confidence 0.76 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0
Thus, understanding the functional significance of higher ACVR2B expression in women will require elucidation of the relative importance of ACVR2A and ACVR2B in myostatin signal transduction in humans, and whether ACVR2B expression is a limiting factor.
Spec (whether) Gene_expression (expression) of ACVR2B
5) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.32 Pain Relevance 0
Here, we report that a myostatin receptor gene, ACVR2B, is expressed at a higher level in women.
Gene_expression (expressed) of ACVR2B
6) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.55 Pain Relevance 0
Thus, understanding the functional significance of higher ACVR2B expression in women will require elucidation of the relative importance of ACVR2A and ACVR2B in myostatin signal transduction in humans, and whether ACVR2B expression is a limiting factor.
Gene_expression (expression) of ACVR2B
7) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.40 Pain Relevance 0
According to this method, GRB10 expression was 2.6-fold greater in the women (P<0.0001), and ACVR2B expression was 1.6-fold greater (P<0.01).
Gene_expression (expression) of ACVR2B
8) Confidence 0.76 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.07 Pain Relevance 0
In an independent microarray study of 10 men and 9 women with facioscapulohumeral dystrophy, women had higher expression of GRB10 (2.7-fold, P<0.001) and ACVR2B (1.7-fold, P<0.03).
Gene_expression (expression) of ACVR2B
9) Confidence 0.66 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0
In mice, knockout of either activin A receptor IIA (ACVR2A) or ACVR2B causes muscle hypertrophy [38].
Gene_expression (knockout) of ACVR2B in muscle associated with targeted disruption and hypertrophy
10) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.57 Pain Relevance 0
We encourage others who are interested in the sexual dimorphism of muscle to examine mRNA and protein expression of GRB10, ACVR2B, or other genes that were differentially expressed in men and women in the present study.


Spec (examine) Gene_expression (expression) of ACVR2B in muscle
11) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0.09
We encourage others who are interested in the sexual dimorphism of muscle to examine mRNA and protein expression of GRB10, ACVR2B, or other genes that were differentially expressed in men and women in the present study.


Gene_expression (expressed) of ACVR2B in muscle
12) Confidence 0.59 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0.09
The women had higher expression of GRB10 (2.7-fold, P<0.001) and ACVR2B (1.7-fold, P<0.03).
Gene_expression (expression) of ACVR2B
13) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.05 Pain Relevance 0
The protein levels of activin IIB receptor in these tissues were similar (Fig. 8A).
Gene_expression (levels) of IIB receptor
14) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.12 Pain Relevance 0
Eleven month old control mdx hearts and quadriceps were probed for levels of activin IIB receptor.
Gene_expression (levels) of IIB receptor in quadriceps
15) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.12 Pain Relevance 0
A possible mechanism for the observed cardiac hypertrophy is reduced myostatin signaling through the activin IIB receptor which is expressed at similar levels in the heart compared to skeletal muscle (Fig. 8A).
Gene_expression (expressed) of IIB receptor in skeletal muscle associated with coronary heart disease
16) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.48 Pain Relevance 0
A possible mechanism for the observed cardiac hypertrophy is reduced myostatin signaling through the activin IIB receptor which is expressed at similar levels in the heart compared to skeletal muscle (Fig. 8A).
Gene_expression (expressed) of IIB receptor in skeletal muscle associated with coronary heart disease
17) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.48 Pain Relevance 0
+ microglia expressed the (A) type II receptor, ActRIIb, and the (B) type I receptor, Alk2, on the cell surface.
Gene_expression (expressed) of ActRIIb in microglia
18) Confidence 0.09 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.18 Pain Relevance 0.13
, expressed the type II receptor, ActRIIb (Fig. 6A), and the type I receptor Alk2 (ActRI) (Fig. 6B).
Gene_expression (expressed) of ActRIIb
19) Confidence 0.09 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.19 Pain Relevance 0.13
Eleven month old control mdx hearts and quadriceps were probed for levels of activin IIB receptor.
Gene_expression (levels) of IIB receptor in hearts
20) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.12 Pain Relevance 0

General Comments

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