INT218307

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grb10, INSR) endosome (INSR) signal transduction (Grb10)
plasma membrane (INSR) nucleus (INSR) carbohydrate metabolic process (INSR)
Grb10 (Mus musculus)
INSR (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 49.68 Quite Low
Hypertrophy 2 18.40 Low Low
Aging 1 5.00 Very Low Very Low Very Low
Confusion 1 5.00 Very Low Very Low Very Low
Muscular Atrophy 1 5.00 Very Low Very Low Very Low
Hyperinsulinism 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GRB10 also interferes with insulin signaling [31], [32], in part by mediating degradation of the insulin receptor [33], but the 3-fold increase in insulin receptor gene expression in women (Table 2) could serve to minimize any negative effect on insulin sensitivity that increased GRB10 expression might have.
GRB10 Positive_regulation (mediating) of Protein_catabolism (degradation) of insulin receptor
1) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0 Pain Relevance 0

General Comments

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