INT218309

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.78
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, IL6) extracellular region (CRP, IL6) aging (IL6)
CRP (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 68 100.00 Very High Very High Very High
cytokine 6 100.00 Very High Very High Very High
rheumatoid arthritis 60 99.68 Very High Very High Very High
depression 48 95.68 Very High Very High Very High
Catecholamine 2 80.68 Quite High
Inflammatory response 3 41.48 Quite Low
Inflammatory mediators 1 18.04 Low Low
methotrexate 36 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 77 100.00 Very High Very High Very High
Cardiovascular Disease 24 99.76 Very High Very High Very High
Rheumatoid Arthritis 61 99.68 Very High Very High Very High
Acute-phase Reaction 1 96.50 Very High Very High Very High
Depression 118 95.68 Very High Very High Very High
Atherosclerosis 4 93.68 High High
Disease 17 93.04 High High
Increased Venous Pressure Under Development 2 91.80 High High
Synovitis 2 88.84 High High
Obesity 50 83.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-6 (IL-6), an inflammatory cytokine and major inducer of the secretion of CRP, is also associated with CVD [15].
CRP Binding (associated) of Interleukin-6 associated with inflammation, cardiovascular disease and cytokine
1) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.72 Pain Relevance 0.51
Interleukin-6 (IL-6), an inflammatory cytokine and major inducer of the secretion of CRP, is also associated with CVD [15].
CRP Binding (associated) of IL-6 associated with inflammation, cardiovascular disease and cytokine
2) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.72 Pain Relevance 0.51
IL-6 is a major cytokine inducer of acute phase response proteins,20 and it is known to be an endogenous pyrogen.6 Thus, it seems likely that IL-6 plays a role in the systemic and constitutional manifestations of RA.21,22 Finally, IL-6 and CRP are both associated with increased cardiovascular risk.23,24 While this association does not prove causation, this point is of particular interest given the increased burden of atherosclerotic disease observed in RA patients as compared to controls matched for known cardiovascular risk factors.
CRP Binding (associated) of IL-6 associated with acute-phase reaction, atherosclerosis, rheumatoid arthritis, disease and cytokine
3) Confidence 0.10 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857613 Disease Relevance 1.34 Pain Relevance 0.34

General Comments

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