INT218314

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.27
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RBP4) extracellular region (RBP4) embryo development (RBP4)
transmembrane transport (RBP4)
Anatomy Link Frequency
fat 1
RBP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 97.24 Very High Very High Very High
depression 24 82.24 Quite High
Inflammation 28 50.00 Quite Low
tolerance 14 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 59 100.00 Very High Very High Very High
Insulin Resistance 126 99.76 Very High Very High Very High
Iron Overload 14 99.22 Very High Very High Very High
Obesity 200 98.68 Very High Very High Very High
Necrosis 7 95.04 Very High Very High Very High
Cancer 9 94.68 High High
Familial Amyloidotic Polyneuropathy 4 92.44 High High
Amyloidosis 6 87.16 High High
Alzheimer's Dementia 13 81.28 Quite High
Diabetes Mellitus 109 78.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload

OBJECTIVES—The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood.

RBP4 Binding (association) of associated with iron overload and insulin resistance
1) Confidence 0.36 Published 2008 Journal Diabetes Section Title Doc Link PMC2453621 Disease Relevance 0.68 Pain Relevance 0
Consistent with these observations, RBP4 was significantly associated with circulating lactoferrin in obese subjects (r = 0.38, P = 0.004, n = 56; data not shown).
RBP4 Binding (associated) of associated with obesity
2) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.26 Pain Relevance 0
Retinol-binding protein-4 (RBP4), a new fat-derived adipokine that specifically binds to retinol, has recently been reported to provide a link between obesity and insulin resistance (1,2).
RBP4 Binding (binds) of in fat associated with obesity and insulin resistance
3) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.11 Pain Relevance 0
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload

OBJECTIVES—The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood.

retinol-binding protein-4 Binding (association) of associated with iron overload and insulin resistance
4) Confidence 0.36 Published 2008 Journal Diabetes Section Title Doc Link PMC2453621 Disease Relevance 0.68 Pain Relevance 0
An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized.
RBP4 Binding (recognized) of
5) Confidence 0.35 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453621 Disease Relevance 0.58 Pain Relevance 0
The lipocalins (such as RBP4) are a large, diverse, but relatively poorly understood family of small extracellular proteins that are characterized by the ability to bind small hydrophobic molecules, such as retinol (RBP4), and by their binding to specific cell surface receptors.
RBP4 Binding (bind) of
6) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.05 Pain Relevance 0
An interaction between iron and vitamin A status, of which RBP4 is a surrogate, has long been recognized.
RBP4 Binding (interaction) of
7) Confidence 0.35 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453621 Disease Relevance 0.57 Pain Relevance 0
Our study is the first to simultaneously evaluate the association between depressive symptoms and various adipokines (adiponectin, resistin, PAI-1 and RBP4) in general populations.
RBP4 Binding (association) of associated with depression
8) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.39 Pain Relevance 0.24
In addition, TTR is the main carrier of vitamin A by forming a complex with retinol-binding protein (RBP) [9].
retinol-binding protein Binding (complex) of
9) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607018 Disease Relevance 0.94 Pain Relevance 0.09

General Comments

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