INT218315

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Context Info
Confidence 0.76
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 18.19
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RBP4) extracellular region (RBP4) embryo development (RBP4)
transmembrane transport (RBP4)
Anatomy Link Frequency
adipose tissue 7
Plasma 4
monocytes 1
Clara cell 1
RBP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 72 98.20 Very High Very High Very High
abdominal pain 1 89.16 High High
Pain 1 85.44 High High
Inflammation 84 84.12 Quite High
tolerance 42 5.00 Very Low Very Low Very Low
alcohol 24 5.00 Very Low Very Low Very Low
anesthesia 21 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 378 100.00 Very High Very High Very High
Obesity 600 99.98 Very High Very High Very High
Iron Overload 42 98.82 Very High Very High Very High
Diabetes Mellitus 327 98.32 Very High Very High Very High
Depression 177 98.20 Very High Very High Very High
Proteinuria 16 96.48 Very High Very High Very High
Endometriosis (extended) 42 95.96 Very High Very High Very High
Aging 6 93.56 High High
Abdominal Pain 1 89.16 High High
Anaemia 105 88.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, lactoferrin, a well-known iron transport protein and iron donor (24), led to significant RBP4 release in a dose-dependent manner and to increased RBP4 expression in adipose tissue explants.
Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
1) Confidence 0.76 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.25 Pain Relevance 0
RBP4 expression analysis in adipose tissue explants.
Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
2) Confidence 0.76 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.20 Pain Relevance 0
Furthermore, the authors did not see a relationship between adipose tissue RBP4 expression and serum RBP4 levels (7).
Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
3) Confidence 0.76 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.17 Pain Relevance 0
Furthermore, the authors did not see a relationship between adipose tissue RBP4 expression and serum RBP4 levels (7).
Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
4) Confidence 0.76 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.17 Pain Relevance 0
RBP4 expression after deferoxamine treatment was decreased by 30% (P = 0.03) (Fig. 5D).
Gene_expression (expression) of RBP4
5) Confidence 0.76 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.08 Pain Relevance 0
Circulating RBP4 levels and adipose tissue RBP4 expression were raised in several different mouse models of obesity and insulin resistance.
Gene_expression (expression) of RBP4 in adipose tissue associated with obesity and insulin resistance
6) Confidence 0.76 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.19 Pain Relevance 0
After 48 h of incubation, lactoferrin treatment led to a 1.32-fold higher RBP4 expression (P = 0.01) (Fig. 5B).
Gene_expression (expression) of RBP4
7) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.30 Pain Relevance 0
The median (range) for RBP4 in plasma was 21.0 ?
Gene_expression (range) of RBP4 in plasma
8) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.66 Pain Relevance 0
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload

OBJECTIVES—The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood.

Gene_expression (resistance) of retinol-binding protein-4 associated with iron overload and insulin resistance
9) Confidence 0.66 Published 2008 Journal Diabetes Section Title Doc Link PMC2453621 Disease Relevance 0.69 Pain Relevance 0
Circulating RBP4 levels and adipose tissue RBP4 expression were raised in several different mouse models of obesity and insulin resistance.
Gene_expression (levels) of RBP4 in adipose tissue associated with obesity and insulin resistance
10) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.18 Pain Relevance 0
Plasma RBP4 levels in women aged >50 years were found to be significantly higher than those in women aged <50 years.
Gene_expression (levels) of RBP4 in Plasma
11) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.54 Pain Relevance 0
At least two recent studies (7,8) did not observe a relationship between RBP4 and insulin resistance in women.
Gene_expression (resistance) of RBP4 associated with insulin resistance
12) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 1.46 Pain Relevance 0
On multiple regression analyses to predict serum RBP4, log serum ferritin independently contributed to 5% of RBP4 variance (?
Gene_expression (predict) of RBP4
13) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.08 Pain Relevance 0
The iron donor lactoferrin led to increased dose-dependent adipose tissue release of RBP4 (2.4-fold, P = 0.005) and increased RBP4 expression, while apotransferrin and deferoxamine led to decreased RBP4 release.
Gene_expression (expression) of RBP4 in adipose tissue associated with obesity
14) Confidence 0.66 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453621 Disease Relevance 0.52 Pain Relevance 0
Serum RBP4 concentration decreased after iron depletion in type 2 diabetic patients (percent mean difference ?
Gene_expression (concentration) of RBP4 associated with diabetes mellitus
15) Confidence 0.66 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453621 Disease Relevance 0.66 Pain Relevance 0
Interestingly, the lower the serum RBP4 concentration at follow-up the higher the increase in insulin sensitivity (r = ?
Gene_expression (concentration) of RBP4
16) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.26 Pain Relevance 0
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload

OBJECTIVES—The mechanisms behind the association between retinol-binding protein-4 (RBP4) and insulin resistance are not well understood.

Gene_expression (resistance) of RBP4 associated with iron overload and insulin resistance
17) Confidence 0.66 Published 2008 Journal Diabetes Section Title Doc Link PMC2453621 Disease Relevance 0.69 Pain Relevance 0
Serum RBP4 concentration was higher in men than women in parallel to increased ferritin levels.
Gene_expression (concentration) of RBP4
18) Confidence 0.66 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2453621 Disease Relevance 0.68 Pain Relevance 0
Serum RBP4 concentration was higher in men than women (P = 0.001) in parallel to increased ferritin levels (P < 0.0001) (Fig. 3).


Gene_expression (concentration) of RBP4
19) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.12 Pain Relevance 0
Given the interactions between vitamin A and iron, we hypothesized that raised iron stores could be behind the association between increased serum RBP4 concentration and insulin resistance.
Gene_expression (resistance) of RBP4 associated with insulin resistance
20) Confidence 0.66 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.69 Pain Relevance 0

General Comments

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