INT218445

Context Info Confidence 0.75 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 2.21 Pain Relevance 0.45

cell differentiation (Smarcb1) nuclear chromosome (Smarcb1) nucleolus (Smarcb1) nucleus (Smarcb1) cell cycle (Smarcb1)

Smarcb1 (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 3 80.08 anesthesia 4 79.44 imagery 30 76.60 Inflammation 46 70.72 cytokine 15 69.68 ischemia 15 50.00 chemokine 1 39.52 Inflammatory response 8 5.00 rheumatoid arthritis 6 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Cancer 234 99.54 Salivary Gland Disease 22 99.08 Apoptosis 45 94.56 Pressure And Volume Under Development 6 81.52 Hepatocellular Cancer 18 73.92 INFLAMMATION 55 70.72 Targeted Disruption 20 67.36 Liver Cancer 12 60.80 Reperfusion Injury 10 50.00 Adhesions 12 49.12

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Expression of Bcl-2 in I/Ri-rats was also increased in comparison to sham-operated rats, indicative of the initiation of the tissue homeostatic response.

Gene_expression (Expression) of in I

1) Confidence 0.75 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.88 Pain Relevance 0.14

Finally, variability in IxAC expression by individual adult females was observed: individual adult females each expressed different individual or series (up to three) of IxACs although some variants such IxAC-B1 were expressed more often than others.

Gene_expression (expression) of in I

2) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.17 Pain Relevance 0

C-MYC induction preceded integrase expression because the integrase protein can only be detected by Western blot for up to one day after hydrodynamic injection [39].

Gene_expression (detected) of integrase protein

3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 0.42 Pain Relevance 0

C31 integrase protein expression independent of integration activity, we injected the plasmids pCSmI and pLiLucB (Fig. 1b) into a group of C-MYC expressing mice (Fig. 2d, cyan).

Gene_expression (in express) of integrase protein

4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 0.42 Pain Relevance 0.19

We observed a statistically significant increase in tumor latency when inactive integrase protein was present, compared to the saline-only group (p?

Neg (inactive) Gene_expression (present) of integrase protein associated with cancer

5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894073 Disease Relevance 0.31 Pain Relevance 0.13

General Comments

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