INT21845

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Context Info
Confidence 0.22
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.90
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
brain 4
spinal 2
pancreas 2
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 23 99.50 Very High Very High Very High
antinociception 6 99.28 Very High Very High Very High
Spinal cord 12 99.24 Very High Very High Very High
monoamine 2 98.36 Very High Very High Very High
narcan 2 81.04 Quite High
Antinociceptive 2 76.48 Quite High
cytokine 11 62.08 Quite High
opiate 3 54.64 Quite High
antagonist 2 52.32 Quite High
tolerance 15 50.00 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 12 98.38 Very High Very High Very High
Targeted Disruption 6 97.44 Very High Very High Very High
Autoimmune Disease 16 91.68 High High
Lymphopenia 18 56.32 Quite High
Influenza Virus Infection 70 50.00 Quite Low
Immunization 4 45.92 Quite Low
Weight Loss 14 23.56 Low Low
Body Weight 6 15.44 Low Low
Cancer 1 14.64 Low Low
Infection 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine (1-50 mg/kg, s.c.) administered alone caused no significant change in the steady-state levels of HA and its major metabolite, tele-methylhistamine (t-MH), in the brain.
Neg (no) Regulation (change) of Gene_expression (levels) of HA in brain associated with morphine
1) Confidence 0.22 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4031857 Disease Relevance 0 Pain Relevance 0.59
The monoamine oxidase (MAO) inhibitor pargyline (used to estimate t-MH synthesis rates) had no effect on HA or t-MH levels in the DBA or C57 spinal cord, indicating the absence of detectable spinal HA turnover.
Neg (no) Regulation (effect) of Gene_expression (levels) of HA in spinal associated with spinal cord and monoamine
2) Confidence 0.17 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.17 Pain Relevance 1.22
Surprisingly, there was little change in the dissociation rate of VLP elicited antibodies when tested against the heterologous Viet Nam clade 1 HA antigen (3.01×10?
Regulation (heterologous) of Gene_expression (antigen) of HA
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2200794 Disease Relevance 0.07 Pain Relevance 0
In DBA (a strain highly sensitive to morphine antinociception), morphine (10 mg/kg, s.c.) had no effect on brain regional t-MH or HA levels, but produced a generalized inhibition of regional t-MH synthesis rates ranging from 11 to 53%.
Neg (no) Regulation (effect) of Gene_expression (levels) of HA in brain associated with antinociception, sprains and strains and morphine
4) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.19 Pain Relevance 0.93
This was evaluated by transfer of transgenic Clone 4 CD8+ T cells bearing an inluenza virus hemagglutinin (HA)-specific, H2-Kd restricted TCR into lymphopenic mice wherein HA is expressed under the control of the rat insulin promoter in the beta cells of the pancreas (termed InsHA mice).
Regulation (under) of Gene_expression (expressed) of HA in pancreas associated with targeted disruption
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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