INT218463

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.31
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cfb) peptidase activity (Cfb) extracellular space (Cfb)
extracellular region (Cfb)
Anatomy Link Frequency
Iris 2
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 89.76 High High
cytokine 4 84.44 Quite High
Inflammation 72 69.68 Quite High
depression 2 59.44 Quite High
Arthritis 2 33.56 Quite Low
ischemia 18 33.36 Quite Low
Dysuria 2 27.36 Quite Low
rheumatoid arthritis 36 27.28 Quite Low
antagonist 6 25.92 Quite Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 6 99.64 Very High Very High Very High
American Trypanosomiasis 6 95.68 Very High Very High Very High
Pox Virus Infection 6 92.24 High High
Bites And Stings 18 92.16 High High
Cv General 3 Under Development 6 89.76 High High
Apoptosis 18 86.92 High High
Edema 4 85.76 High High
Bacterial Infection 2 83.60 Quite High
Targeted Disruption 32 73.76 Quite High
INFLAMMATION 84 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It acts via three mechanisms: preventing the formation of the C3 convertase by binding to C4b; accelerating the natural decay of the classical pathway C3 convertase; and as a cofactor for the serine proteinase factor I in the proteolytic inactivation of C4b, which prevents the formation of the C3 convertase.
Negative_regulation (prevents) of convertase Binding (formation) of
1) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.42 Pain Relevance 0.09
It acts via three mechanisms: preventing the formation of the C3 convertase by binding to C4b; accelerating the natural decay of the classical pathway C3 convertase; and as a cofactor for the serine proteinase factor I in the proteolytic inactivation of C4b, which prevents the formation of the C3 convertase.
Negative_regulation (preventing) of convertase Binding (formation) of
2) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.53 Pain Relevance 0.07
Nevertheless, it remains to be seen whether IxACs can also interfere with the binding of properdin to the target surface.
Negative_regulation (interfere) of properdin Binding (binding) of
3) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.46 Pain Relevance 0.11
Increasing amounts of IRAC II, IxAC-B1 but not Iris lead to a decrease in the amount of bound properdin.
Negative_regulation (decrease) of properdin Binding (bound) of in Iris
4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
They all inhibited formation of C3 convertase by specifically binding to properdin.
Negative_regulation (inhibited) of properdin Binding (binding) of
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.18 Pain Relevance 0
The latter expresses a 160 kDa homolog of DAF which binds to C3b and C4b and prevents formation of the convertase [60].
Negative_regulation (prevents) of convertase Binding (formation) of
6) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.25 Pain Relevance 0
Surface protein gC of Herpes Simplex Virus binds to C3b and inhibits its association with C5 and properdin [59].
Negative_regulation (inhibits) of properdin Binding (association) of associated with herpes simplex virus
7) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.29 Pain Relevance 0
They all inhibited formation of C3 convertase by specifically binding to properdin.
Negative_regulation (inhibited) of convertase Binding (formation) of
8) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.18 Pain Relevance 0

General Comments

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