INT21848

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Context Info
Confidence 0.27
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.97
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 1
Artmd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 6 99.24 Very High Very High Very High
Morphine 57 98.22 Very High Very High Very High
ischemia 4 97.24 Very High Very High Very High
Antinociceptive 1 94.16 High High
Catechol-O-methyltransferase 46 92.72 High High
Dopamine 11 91.44 High High
Ventral tegmentum 5 88.80 High High
monoamine 1 88.20 High High
Nucleus accumbens 24 87.52 High High
Arthritis 61 83.68 Quite High
Disease Link Frequency Relevance Heat
Disease 27 98.70 Very High Very High Very High
Cv Unclassified Under Development 4 97.24 Very High Very High Very High
Sprains And Strains 102 93.16 High High
Aggression 1 89.84 High High
Prostate Cancer 55 87.88 High High
Urological Neuroanatomy 10 86.32 High High
Cancer 38 84.76 Quite High
Arthritis 75 83.68 Quite High
INFLAMMATION 14 81.88 Quite High
Osteoporosis 1 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This gene list includes DUSP1, BTG2, IER2, PTGS2, NR4A1, AMD1, C20orf35, KLF4, RAB4A, KLF6, CTGF and GOLPH2.
Positive_regulation (includes) of AMD1
1) Confidence 0.27 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.94 Pain Relevance 0.17
Morphine (10 mg/kg) had no effect on DBA or C57 spinal cord HA or t-MH levels, but significantly increased t-MH synthesis in the DBA but not in the C57 spinal cord.
Positive_regulation (increased) of DBA in spinal cord associated with spinal cord and morphine
2) Confidence 0.05 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.16 Pain Relevance 1.31
Similarly, Gabra2 was observed to be upregulated in DBA, as compared to C57, in that study as well.
Positive_regulation (upregulated) of DBA
3) Confidence 0.02 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.23 Pain Relevance 0.73
In late disease (6 to 8 weeks after onset), titres of both IgG1 and IgG2a/c had increased modestly in DBA/1 mice.
Positive_regulation (increased) of DBA/1 associated with disease
4) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.64 Pain Relevance 0.35

General Comments

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