INT218480

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 41 31.44 Quite Low
ischemia 12 29.52 Quite Low
rheumatoid arthritis 24 23.44 Low Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Infection 24 92.16 High High
Infection 11 82.00 Quite High
Hepatitis 2 81.00 Quite High
Necrosis 8 80.48 Quite High
Diabetes Mellitus 4 80.44 Quite High
Disease 64 75.00 Quite High
Injury 16 74.48 Quite High
Death 9 70.96 Quite High
Sepsis 7 69.04 Quite High
Targeted Disruption 8 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, these results show that I. ricinus IxAC proteins inhibit the formation of the C3 convertase complex by interacting specifically with properdin.
Negative_regulation (inhibit) of C3 Binding (formation) of
1) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Our study of this action mechanism showed that IxAC molecules bind specifically to properdin, preventing its association with C3 and thereby reducing formation of C3 convertase complex to levels observed in the absence of properdin.
Negative_regulation (reducing) of C3 Binding (formation) of
2) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.05 Pain Relevance 0
Our study of this action mechanism showed that IxAC molecules bind specifically to properdin, preventing its association with C3 and thereby reducing formation of C3 convertase complex to levels observed in the absence of properdin.
Negative_regulation (preventing) of C3 Binding (association) of
3) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
They all inhibited formation of C3 convertase by specifically binding to properdin.
Negative_regulation (inhibited) of C3 Binding (formation) of
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.18 Pain Relevance 0
Protein M diminishes activation of the alternative pathway in the complement system, by inhibiting the binding of the C3 component to the microbe cells and increasing their resistance to phagocytosis.
Negative_regulation (inhibiting) of C3 Binding (binding) of
5) Confidence 0.08 Published 2008 Journal Cases J Section Body Doc Link PMC2547098 Disease Relevance 1.31 Pain Relevance 0

General Comments

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