INT21850

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Context Info
Confidence 0.50
First Reported 1985
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 107
Total Number 121
Disease Relevance 51.40
Pain Relevance 11.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
neurons 13
brain 7
fibroblasts 5
joints 4
T cells 4
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 196 99.80 Very High Very High Very High
imagery 181 99.56 Very High Very High Very High
nMDA receptor 14 99.56 Very High Very High Very High
Neurotransmitter 96 99.40 Very High Very High Very High
Spinal cord 12 99.24 Very High Very High Very High
Pain 183 98.94 Very High Very High Very High
Morphine 23 98.84 Very High Very High Very High
Hippocampus 236 98.80 Very High Very High Very High
agonist 89 98.72 Very High Very High Very High
antinociception 6 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 2699 100.00 Very High Very High Very High
Cancer 1040 99.98 Very High Very High Very High
B-cell Lymphoma 4 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 45 99.74 Very High Very High Very High
Toxicity 47 99.68 Very High Very High Very High
Disease 1519 99.48 Very High Very High Very High
Targeted Disruption 297 99.48 Very High Very High Very High
Influenza In Birds 205 99.48 Very High Very High Very High
Immunization 930 99.44 Very High Very High Very High
Neurodegenerative Disease 168 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine (1-50 mg/kg, s.c.) administered alone caused no significant change in the steady-state levels of HA and its major metabolite, tele-methylhistamine (t-MH), in the brain.
Gene_expression (levels) of HA in brain associated with morphine
1) Confidence 0.50 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4031857 Disease Relevance 0 Pain Relevance 0.59
In humans, it is reported that urinary excretion of homocysteine is much slower than that of mice [7], which suggests that humans may produce greater HA level than mice, since HA is known to be produced from homocysteine.
Gene_expression (produce) of HA
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.28 Pain Relevance 0.11
In humans, it is reported that urinary excretion of homocysteine is much slower than that of mice [7], which suggests that humans may produce greater HA level than mice, since HA is known to be produced from homocysteine.
Gene_expression (produced) of HA
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.29 Pain Relevance 0.12
We previously observed the production of HA by cystathionine-?
Gene_expression (production) of HA
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.23 Pain Relevance 0
The brain HA production in the 3xTg-AD mice was increased by feeding them with a vitamin B6-deficient diet for 3 weeks.
Gene_expression (production) of HA in brain associated with disease
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.14 Pain Relevance 0.11
We measured HA levels in the brains of 4-month-old 3xTg-AD-homozygous mice.
Gene_expression (levels) of HA in brains associated with disease
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 0.54 Pain Relevance 0
In conclusion, (i) HA accelerates pathological changes in AD; and (ii) HA toxicity decreases with anti-HA antibody, which induces strong neurogenesis in the hippocampus, resulting in marked recovery of memory performance.
Gene_expression (antibody) of anti-HA in hippocampus associated with cognitive disorder, toxicity, hippocampus, neurodegenerative disease and disease
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.23 Pain Relevance 0.47
Then anti-HA antibody and HA vaccine also may induce neurogenesis according to the observation of Qu K et al. [15]
Gene_expression (antibody) of anti-HA associated with neurodegenerative disease
8) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.31 Pain Relevance 0.50
Results show the strong anti-pain effect of HA vaccine (Table 5), which suggests that HA vaccine (anti-HA antibody) induced the neurogenesis of hippocampus; this suggestion is consistent with our observation that the hippocampal volume of the experimental mice is larger than that of the control mice.
Gene_expression (antibody) of anti-HA in hippocampus associated with pain, hippocampus and neurodegenerative disease
9) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.43 Pain Relevance 0.47
Results show the strong anti-pain effect of HA vaccine (Table 5), which suggests that HA vaccine (anti-HA antibody) induced the neurogenesis of hippocampus; this suggestion is consistent with our observation that the hippocampal volume of the experimental mice is larger than that of the control mice.
Gene_expression (antibody) of HA vaccine in hippocampus associated with pain, hippocampus and neurodegenerative disease
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.44 Pain Relevance 0.47
These pathological changes as well as cognitive impairments were significantly mitigated by concomitant intracranial injections of anti-HA antibody in these mice.
Gene_expression (antibody) of anti-HA associated with cognitive disorder
11) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.13 Pain Relevance 0.07
(HA vaccine administered to 12-month-old 3xTg-AD mice, and three months later the urinary HA level was measured; Table 3) Also HA vaccine specifically decreased HA level in mice brain at 12 months old (Table 3b).


Gene_expression (level) of HA in brain associated with disease
12) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.17 Pain Relevance 0.05
Then why did the HA level increase in 3xTg-AD mice?
Gene_expression (level) of HA associated with disease
13) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.12 Pain Relevance 0
Then anti-HA antibody and HA vaccine also may induce neurogenesis according to the observation of Qu K et al. [15]
Gene_expression (antibody) of HA vaccine associated with neurodegenerative disease
14) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.31 Pain Relevance 0.50
were to be decreased, HA would still be present in the affected brain tissue.
Gene_expression (present) of HA in brain
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.55 Pain Relevance 0.26
The monoamine oxidase (MAO) inhibitor pargyline (used to estimate t-MH synthesis rates) had no effect on HA or t-MH levels in the DBA or C57 spinal cord, indicating the absence of detectable spinal HA turnover.
Gene_expression (levels) of HA in spinal associated with spinal cord and monoamine
16) Confidence 0.30 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.17 Pain Relevance 1.22
For the generation of recombinant BVs (rBVs) expressing HA, NA, M1 respectively, recombinant Bacmid baculovirus DNAs (rAcNPV) were isolated from transformed DH10Bac cells with pFastBac plasmid constructs and used to transfect Spodoptera frugiperda Sf9 insect cells following the manufacturer's instructions (Invitrogen).
Gene_expression (expressing) of HA
17) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.11 Pain Relevance 0
To produce influenza H5N1 VLPs, Sf9 insect cells were co-infected with rBVs expressing HA, NA, and M1, and VLPs were harvested from the culture supernatants by centrifugation and purified using sucrose gradient ultracentrifugation as described [29], [30].
Gene_expression (expressing) of HA associated with influenza virus infection
18) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.25 Pain Relevance 0
The HA encoding gene in the pCI vector was treated with Xho I, Klenow polymerase fragment, then subsequently digested with Sal I, and cloned into the pFastBac plasmid, a baculovirus (BV) transfer vector (Invitrogen).
Gene_expression (treated) of HA
19) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.09 Pain Relevance 0
In DBA (a strain highly sensitive to morphine antinociception), morphine (10 mg/kg, s.c.) had no effect on brain regional t-MH or HA levels, but produced a generalized inhibition of regional t-MH synthesis rates ranging from 11 to 53%.
Gene_expression (levels) of HA in brain associated with antinociception, sprains and strains and morphine
20) Confidence 0.20 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.19 Pain Relevance 0.93

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