INT218510

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.53
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C3, Cfb) extracellular region (C3, Cfb) cell proliferation (Cfb)
peptidase activity (Cfb) signal transduction (C3)
C3 (Homo sapiens)
Cfb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 81.40 Quite High
Inflammatory response 14 60.80 Quite High
Pain 7 58.92 Quite High
rheumatoid arthritis 42 5.00 Very Low Very Low Very Low
ischemia 21 5.00 Very Low Very Low Very Low
psoriasis 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 7 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 14 83.48 Quite High
INFLAMMATION 84 81.40 Quite High
Pruritus 7 59.36 Quite High
Pain 7 58.92 Quite High
Increased Venous Pressure Under Development 7 54.48 Quite High
Targeted Disruption 14 48.56 Quite Low
Tick Paralysis 7 21.00 Low Low
Exsanguination 7 17.96 Low Low
Disease 105 16.64 Low Low
Theileriasis 14 11.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
C3 (H2O) binds soluble factor B (fB).
C3 Binding (binds) of factor B
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.45 Pain Relevance 0.15
These proteins have a novel action mechanism as they specifically bind to properdin, leading to the inhibition of C3 convertase and the alternative complement pathway.
C3 Binding (bind) of properdin
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2151134 Disease Relevance 0.08 Pain Relevance 0.04
Our study of this action mechanism showed that IxAC molecules bind specifically to properdin, preventing its association with C3 and thereby reducing formation of C3 convertase complex to levels observed in the absence of properdin.
C3 Binding (association) of properdin
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
IxAC proteins inhibit the formation of the C3 convertase complex by interacting with properdin
C3 Binding (complex) of convertase
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
IxAC proteins inhibit the formation of the C3 convertase complex by interacting with properdin
C3 Binding (complex) of convertase
5) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Deposition of C3b and fB on agarose-coated microplates was used to measure AP activation and C3 convertase formation.
C3 Binding (formation) of convertase
6) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Deposition of C3b and fB on agarose-coated microplates was used to measure AP activation and C3 convertase formation.
C3 Binding (formation) of convertase
7) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0

General Comments

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