INT21852

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Context Info
Confidence 0.18
First Reported 1990
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap3d1) transport (Ap3d1) vesicle-mediated transport (Ap3d1)
Golgi apparatus (Ap3d1) cytoplasm (Ap3d1)
Anatomy Link Frequency
spinal 2
muscle 2
Ap3d1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 5 99.24 Very High Very High Very High
sodium channel 5 99.02 Very High Very High Very High
monoamine 1 98.36 Very High Very High Very High
Morphine 8 92.88 High High
antinociception 3 89.20 High High
halothane 15 82.56 Quite High
Antinociceptive 1 76.48 Quite High
opiate 1 54.64 Quite High
antagonist 3 52.32 Quite High
anesthesia 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 169 100.00 Very High Very High Very High
Muscle Rigidity 18 99.48 Very High Very High Very High
Contracture 10 89.84 High High
Sprains And Strains 2 87.40 High High
Congenital Anomalies 3 86.32 High High
Syndrome 21 72.72 Quite High
Central Core Disease 22 5.00 Very Low Very Low Very Low
Fever 16 5.00 Very Low Very Low Very Low
Hyperkalemia 14 5.00 Very Low Very Low Very Low
Rhabdomyolysis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The monoamine oxidase (MAO) inhibitor pargyline (used to estimate t-MH synthesis rates) had no effect on HA or t-MH levels in the DBA or C57 spinal cord, indicating the absence of detectable spinal HA turnover.
Neg (no) Regulation (effect) of Gene_expression (levels) of t-MH in spinal associated with spinal cord and monoamine
1) Confidence 0.18 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.17 Pain Relevance 1.22
Changes in sodium channel function, either through sodium channel mutations or through effects of fatty acids may influence the phenotypic expression of MH, especially muscle rigidity.


Spec (may) Regulation (influence) of Gene_expression (expression) of MH in muscle associated with sodium channel, malignant hyperthermia and muscle rigidity
2) Confidence 0.04 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.16 Pain Relevance 0.32

General Comments

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