INT21853

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Context Info
Confidence 0.10
First Reported 1990
Last Reported 2007
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.40
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap3d1) transport (Ap3d1) vesicle-mediated transport (Ap3d1)
Golgi apparatus (Ap3d1) cytoplasm (Ap3d1)
Anatomy Link Frequency
neuronal 1
spinal cord 1
brain 1
Ap3d1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 24 100.00 Very High Very High Very High
Spinal cord 15 100.00 Very High Very High Very High
antinociception 9 99.28 Very High Very High Very High
monoamine 3 91.00 High High
Antinociceptive 3 89.20 High High
sodium channel 5 86.48 High High
halothane 15 81.40 Quite High
opiate 3 67.36 Quite High
antagonist 5 65.04 Quite High
Calcium channel 3 56.04 Quite High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 169 100.00 Very High Very High Very High
Sprains And Strains 6 98.38 Very High Very High Very High
Syndrome 21 48.16 Quite Low
Congenital Anomalies 3 21.36 Low Low
Stress 12 20.36 Low Low
Targeted Disruption 2 14.76 Low Low
Central Core Disease 22 5.00 Very Low Very Low Very Low
Muscle Rigidity 18 5.00 Very Low Very Low Very Low
Fever 16 5.00 Very Low Very Low Very Low
Hyperkalemia 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine (10 mg/kg) had no effect on DBA or C57 spinal cord HA or t-MH levels, but significantly increased t-MH synthesis in the DBA but not in the C57 spinal cord.
Neg (no) Regulation (effect) of t-MH in spinal cord associated with spinal cord and morphine
1) Confidence 0.10 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.16 Pain Relevance 1.29
In DBA (a strain highly sensitive to morphine antinociception), morphine (10 mg/kg, s.c.) had no effect on brain regional t-MH or HA levels, but produced a generalized inhibition of regional t-MH synthesis rates ranging from 11 to 53%.
Neg (no) Regulation (effect) of t-MH in brain associated with antinociception, sprains and strains and morphine
2) Confidence 0.10 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.19 Pain Relevance 0.93
The effects of morphine on the levels of histamine (HA), its metabolite tele-methylhistamine (t-MH) and on t-MH synthesis rates (thought to be indicative of neuronal HA release) were investigated in brain regions and spinal cords of DBA/2J (DBA) and C57/BL6 (C57) mice, two strains known to differ in their sensitivity to morphine.
Spec (investigated) Regulation (effects) of t-MH in neuronal associated with sprains and strains and morphine
3) Confidence 0.10 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.17 Pain Relevance 0.59
Although mutations in the ryanodine receptor are undoubtedly important in the pathophysiology of MH, it is also clear that not all families demonstrate linkage to this gene.
Regulation (important) of MH associated with malignant hyperthermia
4) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.87 Pain Relevance 0.14

General Comments

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