INT21854

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 0.14
Pain Relevance 4.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
neuronal 2
nerve 2
brain 2
external 2
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 10 99.84 Very High Very High Very High
Spinal cord 5 99.76 Very High Very High Very High
Morphine 8 99.32 Very High Very High Very High
agonist 12 99.20 Very High Very High Very High
Antinociceptive 1 98.96 Very High Very High Very High
Opioid 12 98.88 Very High Very High Very High
narcan 12 98.16 Very High Very High Very High
antinociception 3 92.88 High High
opiate 1 85.52 High High
Enkephalin 16 84.44 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 2 71.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At low concentrations of glucose, the K+ (20 mM)-induced HA release from the hypothalamic slices was also enhanced.
Positive_regulation (enhanced) of Localization (release) of HA
1) Confidence 0.61 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2430060 Disease Relevance 0 Pain Relevance 0.10
At low concentrations of glucose, the K+ (20 mM)-induced HA release from the hypothalamic slices was also enhanced.
Positive_regulation (induced) of Localization (release) of HA
2) Confidence 0.61 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2430060 Disease Relevance 0 Pain Relevance 0.10
The rate of the HA release was dependent on the absolute concentration of glucose and not on an abrupt change in the concentration.
Positive_regulation (dependent) of Localization (release) of HA
3) Confidence 0.47 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2430060 Disease Relevance 0 Pain Relevance 0.07
The possibility that the release of HA from the mouse hypothalamus is regulated by glucose concentration and that activation of neuronal Na+ channels is involved in the enhancement of the HA release by low glucose concentrations warrants further attention.
Positive_regulation (enhancement) of Localization (release) of HA in neuronal
4) Confidence 0.47 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2430060 Disease Relevance 0 Pain Relevance 0.09
The release of HA from this preparation depended on the temperature and Ca2+ in the medium and was progressively increased with decrease in the glucose concentration from 11.5 to 1 mM.
Positive_regulation (increased) of Localization (release) of HA
5) Confidence 0.41 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2430060 Disease Relevance 0 Pain Relevance 0.07
The HA and tele-methylhistamine released from whole blocks of the hypothalamus into the medium linearly increased during 2-h incubation in normal Krebs-Ringer bicarbonate solution in the absence of external depolarizing stimuli.
Positive_regulation (increased) of Localization (released) of HA in external
6) Confidence 0.41 Published 1986 Journal J. Neurochem. Section Abstract Doc Link 2430060 Disease Relevance 0 Pain Relevance 0
The enhancement of HA release induced by DAGO (10(-6) M) was blocked completely by naloxone (10(-6) M) but not by tetrodotoxin (10(-6) M).
Positive_regulation (induced) of Localization (release) of HA associated with tetrodotoxin and narcan
7) Confidence 0.19 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2855235 Disease Relevance 0 Pain Relevance 0.80
The enhancement of HA release induced by DAGO (10(-6) M) was blocked completely by naloxone (10(-6) M) but not by tetrodotoxin (10(-6) M).
Positive_regulation (enhancement) of Localization (release) of HA associated with tetrodotoxin and narcan
8) Confidence 0.19 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2855235 Disease Relevance 0 Pain Relevance 0.80
DAGO (10(-7) and 10(-6) M) significantly increased the K+ (30 mM)-evoked HA release from mouse cerebral cortical slices without influencing on the spontaneous HA release.
Positive_regulation (increased) of Localization (release) of HA
9) Confidence 0.19 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2855235 Disease Relevance 0 Pain Relevance 0.81
These results suggest that opioids with mu agonist activity increase brain HA turnover by facilitating HA release from nerve endings.
Positive_regulation (facilitating) of Localization (release) of HA in nerve associated with agonist and opioid
10) Confidence 0.17 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2855235 Disease Relevance 0 Pain Relevance 0.69
These results suggest that in DBA mice, antinociceptive doses of morphine inhibit HA release in brain, and promote the release of HA from spinal cord.
Positive_regulation (promote) of Localization (release) of HA in brain associated with antinociceptive, spinal cord and morphine
11) Confidence 0.16 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.14 Pain Relevance 1.33

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