INT21855

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Context Info
Confidence 0.32
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 12.21
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (Ap3d1) transport (Ap3d1) vesicle-mediated transport (Ap3d1)
Golgi apparatus (Ap3d1) cytoplasm (Ap3d1)
Anatomy Link Frequency
muscle 3
spinal 1
spinal cord 1
brain 1
reticulum 1
Ap3d1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 15 99.24 Very High Very High Very High
Morphine 24 99.00 Very High Very High Very High
antinociception 9 98.78 Very High Very High Very High
sodium channel 40 98.52 Very High Very High Very High
monoamine 3 98.04 Very High Very High Very High
halothane 120 97.92 Very High Very High Very High
Antinociceptive 3 93.28 High High
anesthesia 184 93.20 High High
opiate 3 71.44 Quite High
antagonist 19 69.12 Quite High
Disease Link Frequency Relevance Heat
Malignant Hyperthermia 1352 100.00 Very High Very High Very High
Muscle Rigidity 144 99.90 Very High Very High Very High
Rhabdomyolysis 112 99.86 Very High Very High Very High
Burns 8 99.84 Very High Very High Very High
Sprains And Strains 6 97.88 Very High Very High Very High
Emergencies 24 94.40 High High
Central Core Disease 176 92.88 High High
Dyspnea 24 91.12 High High
Muscle Disease 80 90.40 High High
Contracture 80 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The monoamine oxidase (MAO) inhibitor pargyline (used to estimate t-MH synthesis rates) had no effect on HA or t-MH levels in the DBA or C57 spinal cord, indicating the absence of detectable spinal HA turnover.
Gene_expression (levels) of t-MH in spinal associated with spinal cord and monoamine
1) Confidence 0.32 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.17 Pain Relevance 1.22
Morphine (10 mg/kg) had no effect on DBA or C57 spinal cord HA or t-MH levels, but significantly increased t-MH synthesis in the DBA but not in the C57 spinal cord.
Gene_expression (synthesis) of t-MH in spinal cord associated with spinal cord and morphine
2) Confidence 0.25 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.15 Pain Relevance 1.30
In DBA (a strain highly sensitive to morphine antinociception), morphine (10 mg/kg, s.c.) had no effect on brain regional t-MH or HA levels, but produced a generalized inhibition of regional t-MH synthesis rates ranging from 11 to 53%.
Gene_expression (levels) of t-MH in brain associated with antinociception, sprains and strains and morphine
3) Confidence 0.21 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.19 Pain Relevance 0.93
Changes in sodium channel function, either through sodium channel mutations or through effects of fatty acids may influence the phenotypic expression of MH, especially muscle rigidity.


Gene_expression (expression) of MH in muscle associated with sodium channel, malignant hyperthermia and muscle rigidity
4) Confidence 0.11 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.16 Pain Relevance 0.32
The clinical expression of MH is also poorly understood.
Gene_expression (expression) of MH associated with malignant hyperthermia
5) Confidence 0.11 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.93 Pain Relevance 0.15
However, MH-like muscle responses can represent false positive diagnoses and an underlying myopathic process may produce a positive IVCT [79], so there must remain some doubt on the validity of this feature i.e. rhabdomyolysis as an expression of MH.
Gene_expression (expression) of MH in muscle associated with rhabdomyolysis and malignant hyperthermia
6) Confidence 0.11 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.69 Pain Relevance 0.17
Genotype-phenotype correlations are weak for both the clinical expression of MH and the response of isolated muscle to caffeine or halothane.
Gene_expression (expression) of MH in muscle associated with halothane and malignant hyperthermia
7) Confidence 0.11 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.88 Pain Relevance 0.19
Acute MH crisis
Gene_expression (crisis) of MH associated with malignant hyperthermia
8) Confidence 0.08 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 0.65 Pain Relevance 0
Dantrolene should be administered if the other signs of MH occur along with MMR.
Gene_expression (occur) of MH associated with malignant hyperthermia and muscle rigidity
9) Confidence 0.08 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 2.13 Pain Relevance 0.16
Since MMR may presage MH, it is most advisable to discontinue the anesthetic after MMR.
Gene_expression (presage) of MH associated with malignant hyperthermia and muscle rigidity
10) Confidence 0.08 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 2.41 Pain Relevance 0.22
Experimental evidence from a variety of sources, in vitro, in vivo, isolated cells, transfected cells and mice who's DNA has been altered to express one of the MH causative mutations clearly indicates that the signs and symptoms of MH are related to an uncontrolled release of intracellular calcium from skeletal muscle sarcoplasmic reticulum (SR).
Gene_expression (express) of MH in reticulum associated with malignant hyperthermia
11) Confidence 0.08 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.85 Pain Relevance 0

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