INT21856

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Context Info
Confidence 0.51
First Reported 1985
Last Reported 2010
Negated 6
Speculated 2
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 3.74
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
brain 4
neuronal 1
spinal cord 1
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 38 100.00 Very High Very High Very High
Spinal cord 19 100.00 Very High Very High Very High
antinociception 9 99.28 Very High Very High Very High
narcan 7 92.56 High High
monoamine 3 91.36 High High
tetrodotoxin 1 90.08 High High
Antinociceptive 3 88.56 High High
Opioid 3 85.92 High High
Pain 13 84.96 Quite High
agonist 7 84.64 Quite High
Disease Link Frequency Relevance Heat
Disease 174 99.64 Very High Very High Very High
Sprains And Strains 12 98.38 Very High Very High Very High
Influenza In Birds 11 97.24 Very High Very High Very High
Influenza Virus Infection 135 94.96 High High
Shock 2 92.24 High High
Alzheimer's Dementia 14 87.52 High High
Nociception 3 86.32 High High
Toxicity 12 85.60 High High
Pain 12 84.96 Quite High
Parkinson's Disease 2 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine (1-50 mg/kg, s.c.) administered alone caused no significant change in the steady-state levels of HA and its major metabolite, tele-methylhistamine (t-MH), in the brain.
Neg (no) Regulation (change) of HA in brain associated with morphine
1) Confidence 0.51 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4031857 Disease Relevance 0 Pain Relevance 0.59
HA affects the two pathophysiological hallmarks of AD and may be involved in its etiology.
Regulation (affects) of HA associated with disease
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.28 Pain Relevance 0
The effect of the acute morphine treatment on histamine (HA) pools in the brain and the spinal cord was examined in mice.
Spec (examined) Regulation (effect) of HA in brain associated with spinal cord and morphine
3) Confidence 0.19 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4031857 Disease Relevance 0 Pain Relevance 0.43
DAGO (10(-7) and 10(-6) M) significantly increased the K+ (30 mM)-evoked HA release from mouse cerebral cortical slices without influencing on the spontaneous HA release.
Neg (without) Regulation (influencing) of HA
4) Confidence 0.19 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2855235 Disease Relevance 0 Pain Relevance 0.80
In mice, the exposure to tail pinch markedly increased the brain level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, while the level of HA was not changed.
Neg (not) Regulation (changed) of HA in brain
5) Confidence 0.17 Published 1989 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2470944 Disease Relevance 0.33 Pain Relevance 0.03
The result is shown in Fig. 5, and as clearly seen, there is a strong cure effect of HA vaccine in 3xTg-AD mice (12-month-old).


Regulation (effect) of HA vaccine associated with disease
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.11 Pain Relevance 0.40
In DBA (a strain highly sensitive to morphine antinociception), morphine (10 mg/kg, s.c.) had no effect on brain regional t-MH or HA levels, but produced a generalized inhibition of regional t-MH synthesis rates ranging from 11 to 53%.
Neg (no) Regulation (effect) of HA in brain associated with antinociception, sprains and strains and morphine
7) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.19 Pain Relevance 0.93
The effects of morphine on the levels of histamine (HA), its metabolite tele-methylhistamine (t-MH) and on t-MH synthesis rates (thought to be indicative of neuronal HA release) were investigated in brain regions and spinal cords of DBA/2J (DBA) and C57/BL6 (C57) mice, two strains known to differ in their sensitivity to morphine.
Spec (investigated) Regulation (effects) of HA in neuronal associated with sprains and strains and morphine
8) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.17 Pain Relevance 0.55
Morphine (10 mg/kg) had no effect on DBA or C57 spinal cord HA or t-MH levels, but significantly increased t-MH synthesis in the DBA but not in the C57 spinal cord.
Neg (no) Regulation (effect) of HA in spinal cord associated with spinal cord and morphine
9) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2207651 Disease Relevance 0.16 Pain Relevance 1.29
In attempts to overcome these obstacles, several strategies have been explored including the use of a low pathogenic avian influenza virus [22], baculovirus- expressed H5 HA [23], recombinant adenoviruses [24], [25] and the production of attenuated live seed virus with modified H5 HA [17], [26], [27].
Regulation (modified) of HA associated with influenza in birds
10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.44 Pain Relevance 0
To determine whether the effect of protective oil on virus infectivity was due to alterations in virus particle integrity, the effect of oil treatment on HA activity was assessed.
Regulation (effect) of HA
11) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0.05 Pain Relevance 0
There was a modest effect of a 1 to 1,000 dilution on HA activity after 72 h oil treatment.
Regulation (effect) of HA
12) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0 Pain Relevance 0
Although HA activity decreased with time for all treated and mock treated viruses, there was no significant effect of oil treatment on HA activity (Table 1) at several concentrations that decrease viral infectivity and progeny virus production.
Neg (no) Regulation (effect) of HA
13) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2994788 Disease Relevance 0 Pain Relevance 0

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