INT218578

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.70
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GYPC)
Anatomy Link Frequency
plasma 5
GYPC (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 35 99.60 Very High Very High Very High
Cholecystokinin 465 99.56 Very High Very High Very High
Paracetamol 4 90.08 High High
Opioid 11 84.52 Quite High
cytokine 8 83.76 Quite High
Versed 14 69.16 Quite High
Morphine 14 68.48 Quite High
Bile 149 54.00 Quite High
tolerance 2 48.92 Quite Low
nud 5 29.36 Quite Low
Disease Link Frequency Relevance Heat
Gastric Motility Disorder 210 100.00 Very High Very High Very High
Injury 56 99.20 Very High Very High Very High
Critical Illness 268 98.96 Very High Very High Very High
Sepsis 46 98.86 Very High Very High Very High
Eating Disorder 10 98.70 Very High Very High Very High
Hypoglycemia 5 98.28 Very High Very High Very High
Appetite Loss 10 98.26 Very High Very High Very High
Obesity 22 97.88 Very High Very High Very High
Burns 22 89.48 High High
Brain Injury 29 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On linear regression analysis, GE (both t50 and GEC) correlated with older age, higher admission APACHE II scores, longer length of stay in ICU prior to GE, higher FiO2 (fraction of inspired oxygen) requirement, and higher serum creatinine (Table 3).
Positive_regulation (requirement) of GE associated with gastric motility disorder
1) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.85 Pain Relevance 0.10
However, data on the incidence of delayed GE in patients with other diagnoses such as sepsis and multi-trauma are limited and the techniques used to measure GE in some studies suboptimal.
Positive_regulation (measure) of GE associated with injury, gastric motility disorder and sepsis
2) Confidence 0.37 Published 2007 Journal Crit Care Section Body Doc Link PMC2151889 Disease Relevance 1.62 Pain Relevance 0.21
In general, the received opinion about the mechanism is that local deposits results in CL-GPC.
Positive_regulation (results) of CL-GPC
3) Confidence 0.15 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765629 Disease Relevance 0.08 Pain Relevance 0
As observed in lean [1,2,4,7,11,12] and obese [47] healthy subjects, the present study demonstrates a weak but direct relationship between the rate of GE and postprandial increases in plasma CCK and PYY in critically ill patients.
Positive_regulation (increases) of GE in plasma associated with critical illness, obesity and cholecystokinin
4) Confidence 0.06 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.38 Pain Relevance 0.24
CCK antagonists have been shown to increase GE and energy intake in humans [17-19].
Positive_regulation (increase) of GE associated with antagonist and cholecystokinin
5) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.28 Pain Relevance 0.41
In the fasted state, there is an increase in plasma concentrations of hormones that slow GE, such as CCK and PYY, and a decrease in hormones that may accelerate GE, such as ghrelin [28-30].
Positive_regulation (accelerate) of GE in plasma associated with cholecystokinin
6) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.66 Pain Relevance 0.29
Furthermore, both plasma CCK and PYY concentrations are elevated in patients with chronic nutrient deprivation, malnutrition, and anorexia nervosa [20-22], conditions that are known to be associated with a high prevalence of delayed GE [23,24].
Positive_regulation (prevalence) of GE in plasma associated with appetite loss, cholecystokinin and eating disorder
7) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.48 Pain Relevance 0.38
Whilst insulin-induced hypoglycaemia has no significant effect on antro-pyloro-duodenal motor activity in humans [51], it accelerates GE [52].
Positive_regulation (accelerates) of GE associated with hypoglycemia
8) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.22 Pain Relevance 0.26
Decreases in levels of lipoproteins and pyruvate, and increased levels of GPC, choline, acetate and glutamine were observed in the plasma of HBF mice when compared to conventional animals (Figure 3A and Supplementary Figure 1).
Positive_regulation (increased) of GPC in plasma
9) Confidence 0.02 Published 2007 Journal Mol Syst Biol Section Body Doc Link PMC2673711 Disease Relevance 0.07 Pain Relevance 0.03
Decreased fecal choline was associated with reduced concentrations of TMA and DMA in the liver, an increase in plasma GPC, but with no changes in liver TMAO and plasma choline after L. paracasei supplementation.
Positive_regulation (increase) of GPC in plasma
10) Confidence 0.02 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2238715 Disease Relevance 0.06 Pain Relevance 0

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