INT218587

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 7.40
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cellular_component (Btg2)
Anatomy Link Frequency
lung 3
neurons 1
alveolar wall 1
Btg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 80 97.68 Very High Very High Very High
imagery 12 96.36 Very High Very High Very High
Inflammatory response 32 92.96 High High
Hippocampus 26 84.84 Quite High
nMDA receptor 26 73.04 Quite High
Inflammation 48 55.64 Quite High
withdrawal 22 54.00 Quite High
anesthesia 64 37.36 Quite Low
Action potential 56 5.00 Very Low Very Low Very Low
ketamine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 320 99.68 Very High Very High Very High
Hypocapnia 80 99.66 Very High Very High Very High
Death 198 99.52 Very High Very High Very High
Cancer 2 99.26 Very High Very High Very High
Stress 24 98.82 Very High Very High Very High
Acidosis 32 98.08 Very High Very High Very High
Hypercapnia 64 97.28 Very High Very High Very High
Acid Base Imbalance 32 96.52 Very High Very High Very High
Fibrosis 32 95.40 Very High Very High Very High
Alkalosis 32 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of Btg2, Ifi202b, and Serpinb2 consistently led to neuroprotection also on the contralateral (i.e. non-injected) side (Figure 7, Table 2).
Gene_expression (Expression) of Btg2
1) Confidence 0.11 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.54 Pain Relevance 0.21
Using Rhodamine 123 (Rh123) imaging techniques to monitor the mitochondrial membrane potential, we have recently shown that one mechanism through which down-regulation of the tumor suppressor gene, p53, or increasing expression of Btg2 can enhance the survival of hippocampal neurons involves inhibition of the NMDA-induced break-down of the mitochondrial membrane potentials [51].
Gene_expression (expression) of Btg2 in neurons associated with cancer and imagery
2) Confidence 0.11 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2718706 Disease Relevance 0.69 Pain Relevance 0.15
This might reduce the overdistension observed in nondependent areas in the supine position, thus preventing an excessive activation of PC III mRNA synthesis.
Gene_expression (synthesis) of PC III mRNA
3) Confidence 0.06 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.26 Pain Relevance 0.10
Our main findings were the following: First, upregulation of PC III expression occurred early in this ALI model; second, it was significantly higher in ventilatory strategies that possibly generated overinflation due to the fact that either high PEEP or high VT affected mostly nondependent lung regions of these groups; and third, the prone position partially attenuated this response.
Spec (partially) Gene_expression (expression) of PC III in lung associated with adult respiratory distress syndrome
4) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.10 Pain Relevance 0
Key messages

• Upregulation of PC III expression occurred early in this OA ALI model. • Upregulation of PC III expression was significantly higher in ventilatory strategies that possibly generated overinflation due to the fact that either high PEEP or high VT affected mostly nondependent lung regions of these groups. • The prone position partially attenuated this response.


Gene_expression (expression) of PC III associated with adult respiratory distress syndrome
5) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.88 Pain Relevance 0
We examined whether different high-inflation strategies of mechanical ventilation (MV) in oleic acid (OA) ALI alter regional expression of PC III.


Gene_expression (expression) of PC III associated with adult respiratory distress syndrome
6) Confidence 0.05 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2151905 Disease Relevance 0.46 Pain Relevance 0
Indeed, levels of PC III found in the prone group were similar to the unventilated OA group.
Gene_expression (levels) of PC III
7) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.24 Pain Relevance 0
The expression of PC III was higher in the nondependent region of the LVHP-S and HVLP-S groups compared to the dependent region of the HVLP-S group.
Gene_expression (expression) of PC III
8) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.27 Pain Relevance 0
Control variables were not normally distributed and were described by median and interquartile ranges and compared by Kruskal-Wallis or Mann-Whitney U tests when appropriate. mRNA expressions of PC III and IL-1?
Gene_expression (expressions) of PC III
9) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0 Pain Relevance 0
and PC III mRNA expressions were determined by Northern blot analysis using total RNA [32], the probes previously described [10], and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as control for RNA loading.
Gene_expression (expressions) of PC III mRNA
10) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.05 Pain Relevance 0
We observed that rat lungs ventilated in the prone position showed less upregulation for the expression of PC III as compared to MV with high VT (HVLP-S) or high PEEP (LVHP-S) for the same peak inspiratory pressure.
Gene_expression (expression) of PC III in lungs
11) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.24 Pain Relevance 0
Even supposing that hyper/hypocapnia could alter the expression of PC III, we could assume that in our model these effects were marginal in view of the effects of ventilatory strategy; one hypercapnic group (LVHP-S) and a hypocapnic group (HVLP-S) shared high expressions of PC III and the other hypocapnic group (HVLP-P) had significantly less expression of it.
Gene_expression (expressions) of PC III associated with hypocapnia
12) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 1.09 Pain Relevance 0
In experimental models, increased alveolar wall stress during a four hour period was accompanied by an increased synthesis of PC I, PC III, PC IV, and laminin B [6].
Gene_expression (synthesis) of PC III in alveolar wall associated with stress
13) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.17 Pain Relevance 0
A significant interaction for group and region effects was observed for the expression of PC III (for the interaction p = 0.012, ANOVA two-way) with higher expression in the HVLP-S and LVHP-S groups (group effect, p < 0.00001, ANOVA two-way, partial ?
Gene_expression (expression) of PC III
14) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.34 Pain Relevance 0
Moreover, we found significantly higher expression of PC III mRNA with an effect size of 77% in ventilatory strategies associated with overinflation of lung parenchyma, as we noticed in the HVLP-S and LVHP-S groups, regardless of how high end-inspiratory volume was achieved.
Gene_expression (expression) of PC III mRNA in lung
15) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.19 Pain Relevance 0
Post hoc analysis showed that the expression of PC III was high in the HVLP-S and LVHP-S groups, intermediate in the OA and HVLP-P groups, and low in the control group.
Gene_expression (expression) of PC III
16) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.29 Pain Relevance 0
Even supposing that hyper/hypocapnia could alter the expression of PC III, we could assume that in our model these effects were marginal in view of the effects of ventilatory strategy; one hypercapnic group (LVHP-S) and a hypocapnic group (HVLP-S) shared high expressions of PC III and the other hypocapnic group (HVLP-P) had significantly less expression of it.
Gene_expression (expression) of PC III associated with hypocapnia
17) Confidence 0.05 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 1.22 Pain Relevance 0.06
Expression of PC III for each group and region is shown in Figure 1.
Gene_expression (Expression) of PC III
18) Confidence 0.04 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.37 Pain Relevance 0

General Comments

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