INT218605

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.68
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcna2) transmembrane transport (Kcna2)
Anatomy Link Frequency
cerebral cortex 1
Kcna2 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 5 99.78 Very High Very High Very High
Neuronal excitability 7 99.32 Very High Very High Very High
Demyelination 26 98.40 Very High Very High Very High
potassium channel 11 93.12 High High
Nav1.6 11 69.28 Quite High
Action potential 29 47.84 Quite Low
Multiple sclerosis 28 33.72 Quite Low
Inflammation 20 5.00 Very Low Very Low Very Low
Spinal cord 18 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 217 98.86 Very High Very High Very High
Convulsion 33 98.60 Very High Very High Very High
Demyelinating Disease 59 98.40 Very High Very High Very High
Lifespan 4 93.92 High High
Targeted Disruption 53 92.64 High High
Cognitive Disorder 3 59.68 Quite High
Sleep Disorders 14 24.08 Low Low
Disease 28 5.00 Very Low Very Low Very Low
INFLAMMATION 21 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that while low doses were able to block EEG signs of slow wave sleep, high doses also produced seizures [21], suggesting that an increase in neuronal excitability in the cerebral cortex, due to a block of the Kv1.2-mediated current, is sufficient to trigger seizure activity.
Negative_regulation (block) of Kv1.2-mediated in cerebral cortex associated with convulsion, neuronal excitability and cerebral cortex
1) Confidence 0.41 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.82 Pain Relevance 0.21
Demyelination in vehicle-treated EAE was associated with increased expression of Kv1.2 and a lengthening of Kv1.2 immunostaining across the entire axon length.
Negative_regulation (lengthening) of Kv1.2 associated with multiple sclerosis and demyelination
2) Confidence 0.41 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.86 Pain Relevance 0.34

General Comments

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