INT218605

Context Info Confidence 0.41 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.68 Pain Relevance 0.55

transport (Kcna2) transmembrane transport (Kcna2)

Anatomy Link Frequency cerebral cortex 1 Kcna2 (Mus musculus)

Pain Link Frequency Relevance Heat cerebral cortex 5 99.78 Neuronal excitability 7 99.32 Demyelination 26 98.40 potassium channel 11 93.12 Nav1.6 11 69.28 Action potential 29 47.84 Multiple sclerosis 28 33.72 Inflammation 20 5.00 Spinal cord 18 5.00 Hippocampus 8 5.00

Disease Link Frequency Relevance Heat Multiple Sclerosis 217 98.86 Convulsion 33 98.60 Demyelinating Disease 59 98.40 Lifespan 4 93.92 Targeted Disruption 53 92.64 Cognitive Disorder 3 59.68 Sleep Disorders 14 24.08 Disease 28 5.00 INFLAMMATION 21 5.00 Alzheimer's Dementia 10 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that while low doses were able to block EEG signs of slow wave sleep, high doses also produced seizures [21], suggesting that an increase in neuronal excitability in the cerebral cortex, due to a block of the Kv1.2-mediated current, is sufficient to trigger seizure activity.

Negative_regulation (block) of Kv1.2-mediated in cerebral cortex associated with convulsion, neuronal excitability and cerebral cortex

1) Confidence 0.41 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.82 Pain Relevance 0.21

Demyelination in vehicle-treated EAE was associated with increased expression of Kv1.2 and a lengthening of Kv1.2 immunostaining across the entire axon length.

Negative_regulation (lengthening) of Kv1.2 associated with multiple sclerosis and demyelination

2) Confidence 0.41 Published 2010 Journal Brain Section Body Doc Link PMC2947430 Disease Relevance 0.86 Pain Relevance 0.34

General Comments

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