INT218608

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 5.69
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Swap70) nucleus (Swap70) DNA binding (Swap70)
cytoplasm (Swap70)
Anatomy Link Frequency
eye 1
cerebral cortex 1
striatum 1
hippocampus 1
Swap70 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 25 98.76 Very High Very High Very High
cerebral cortex 15 98.50 Very High Very High Very High
depression 368 98.02 Very High Very High Very High
potassium channel 30 96.36 Very High Very High Very High
Eae 22 90.12 High High
Raphe 8 73.64 Quite High
GABAergic 3 73.20 Quite High
Locus ceruleus 8 73.08 Quite High
amygdala 8 69.44 Quite High
Neuronal excitability 21 21.44 Low Low
Disease Link Frequency Relevance Heat
Depression 440 98.02 Very High Very High Very High
Stress 179 89.28 High High
Sleep Disorders 66 86.00 High High
Disease 48 84.40 Quite High
Affective Disorder 24 83.28 Quite High
Convulsion 99 82.28 Quite High
Targeted Disruption 155 72.44 Quite High
Adrenal Cancer 8 71.20 Quite High
Cushing's Syndrome /

Hypercortisolism

8 70.20 Quite High
Akathisia 32 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, clinical studies also report a reduction in SWA in depressed patients [6], [7], [11], [12], [76], although slow wave sleep is not reduced and REM sleep parameters seem to be less consistently altered in patients with atypical depression [7], [17].
Negative_regulation (reduction) of SWA associated with depression
1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.21 Pain Relevance 0.05
NREM sleep and SWA on the other hand were reduced in comparison to the other two lines.
Negative_regulation (reduced) of SWA
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.20 Pain Relevance 0.08
It is beyond the scope of this study to reveal whether the decreased amounts of NREM sleep can be attributed to attenuated levels of SWA, but this would implicate that reduced SWA is an intrinsic sleep-physiological feature of the HR mouse line, which might be brought about by a chronic activation of the CRH system [6], [75].
Negative_regulation (reduced) of SWA
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.20 Pain Relevance 0.03
In contrast, patients presenting with the so-called atypical subtype of depression are characterised by markedly reduced activity of the HPA axis, while sleep-EEG data suggest that SWA is not reduced and REM sleep parameters are not considerably altered in these patients [7], [15], [17], [28], [29].
Neg (not) Negative_regulation (reduced) of SWA associated with depression
4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.80 Pain Relevance 0.21
They also show a reduced latency to the first episode of rapid eye movement (REM) sleep, an increased proportion of REM sleep (increased REM density and intensity) and reduced slow-wave activity (SWA) during non-REM (NREM) sleep [6], [7], [11], [12].
Negative_regulation (reduced) of SWA in eye
5) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.67 Pain Relevance 0.37
It is beyond the scope of this study to reveal whether the decreased amounts of NREM sleep can be attributed to attenuated levels of SWA, but this would implicate that reduced SWA is an intrinsic sleep-physiological feature of the HR mouse line, which might be brought about by a chronic activation of the CRH system [6], [75].
Negative_regulation (attenuated) of SWA
6) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.20 Pain Relevance 0.03
That is, animals with a greater corticosterone response in the SRT showed a higher CM excretion profile, a greater increase in REM sleep and a stronger decrease in SWA.
Negative_regulation (decrease) of SWA
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.30 Pain Relevance 0.04
These patients also show the most pronounced sleep-EEG alterations, including disrupted sleep, decreased SWA, short REM sleep latency and high REM sleep density.
Negative_regulation (decreased) of SWA
8) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2627900 Disease Relevance 0.86 Pain Relevance 0.24
Mice lacking the potassium channel subunit Kv.3.1, which is expressed in fast-spiking, parvalbumin-containing interneurons in cerebral cortex, hippocampus, striatum, and the thalamic reticular nucleus, show a 20–50% decrease in the EEG power in the slow wave activity (SWA) range (2–3 Hz) [23].
Negative_regulation (decrease) of SWA in striatum associated with hippocampus, potassium channel and cerebral cortex
9) Confidence 0.01 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.71 Pain Relevance 0.30
Mice lacking the potassium channel subunit Kv.3.1, which is expressed in fast-spiking, parvalbumin-containing interneurons in cerebral cortex, hippocampus, striatum, and the thalamic reticular nucleus, show a 20–50% decrease in the EEG power in the slow wave activity (SWA) range (2–3 Hz) [23].
Negative_regulation (decrease) of SWA in hippocampus associated with hippocampus, potassium channel and cerebral cortex
10) Confidence 0.00 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.71 Pain Relevance 0.30
Mice lacking the potassium channel subunit Kv.3.1, which is expressed in fast-spiking, parvalbumin-containing interneurons in cerebral cortex, hippocampus, striatum, and the thalamic reticular nucleus, show a 20–50% decrease in the EEG power in the slow wave activity (SWA) range (2–3 Hz) [23].
Negative_regulation (decrease) of SWA in cerebral cortex associated with hippocampus, potassium channel and cerebral cortex
11) Confidence 0.00 Published 2007 Journal BMC Biol Section Body Doc Link PMC2151933 Disease Relevance 0.71 Pain Relevance 0.30

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