INT218663

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Smad7) plasma membrane (Smad7) nucleus (Smad7)
intracellular (Smad7) protein complex (Smad7) cytoplasm (Smad7)
Olr811 (Rattus norvegicus)
Smad7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 10 14.12 Low Low
metalloproteinase 20 11.68 Low Low
Paracetamol 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 20 87.44 High High
Cirrhosis 72 83.20 Quite High
Cancer 4 74.96 Quite High
Apoptosis 18 48.68 Quite Low
Fibrosis 6 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that NIM811 enhanced the expression of Smad7, and suppressed that of TGF-?
NIM811 Positive_regulation (enhanced) of Gene_expression (expression) of Smad7
1) Confidence 0.01 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.14 Pain Relevance 0
-RI phosphorylation (28). 0.5 mM NIM811 enhanced the expression of Smad7 nearly two-fold (Fig. 7A) and it suppressed that of TGF-?
NIM811 Positive_regulation (enhanced) of Gene_expression (expression) of Smad7
2) Confidence 0.01 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.30 Pain Relevance 0

General Comments

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