INT218664

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
signal transducer activity (Olr811)
Olr811 (Rattus norvegicus)
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 20 97.76 Very High Very High Very High
fibrosis 10 68.12 Quite High
cytokine 2 37.96 Quite Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 72 99.54 Very High Very High Very High
Apoptosis 18 85.92 High High
Fibrosis 6 68.12 Quite High
Hepatitis C Virus Infection 20 52.92 Quite High
Injury 2 7.72 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because commercial kits for the measurement of mouse or rat matrix metalloproteinase 1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were not available, we used TWNT-4 cells, a human cell line derived from HSCs (16), to evaluate the effects of NIM811 on MMP-1 and TIMP-1.
NIM811 Regulation (effects) of TIMP-1 associated with cirrhosis and metalloproteinase
1) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.70 Pain Relevance 0.13
In contrast, 0.5 mM NIM811 increased the expression of MMP-1 nearly two-fold (Fig. 3B) but did not affect that of TIMP-1 (Fig. 3C).
NIM811 Neg (not) Regulation (affect) of TIMP-1
2) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.20 Pain Relevance 0.09

General Comments

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