INT218668

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.98
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppia) protein folding (Ppia) cytosol (Ppia)
nucleus (Ppia) signal transducer activity (Olr811) cytoplasm (Ppia)
Ppia (Rattus norvegicus)
Olr811 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 2 98.28 Very High Very High Very High
fibrosis 10 49.76 Quite Low
Paracetamol 2 17.52 Low Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 20 82.96 Quite High
Cirrhosis 72 80.88 Quite High
Injury 2 68.04 Quite High
Disease Progression 4 60.48 Quite High
Fibrosis 6 49.76 Quite Low
Hepatitis 4 25.80 Quite Low
Necrosis 2 15.76 Low Low
Apoptosis 18 14.72 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NIM811 is a four-substituted cyclosporine that does not bind to cyclophilin A and therefore lacks immunosuppressive activity; however, it retains the ability to bind other cyclophilins, such as cyclophilin B (13).
cyclophilin Neg (not) Binding (bind) of NIM811
1) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.86 Pain Relevance 0.05
Because NIM811 lacks the ability to bind to cyclophilin A (13), NIM811 exerts its pharmacological effects by binding to other cyclophilins, such as cyclophilin B or D.
cyclophilin Binding (bind) of NIM811
2) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.11 Pain Relevance 0

General Comments

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