INT218669

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2) signal transducer activity (Olr811)
Olr811 (Rattus norvegicus)
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 5 29.32 Quite Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 36 99.20 Very High Very High Very High
Apoptosis 9 25.08 Quite Low
Fibrosis 3 15.40 Low Low
Hepatitis C Virus Infection 10 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Hepatitis 2 5.00 Very Low Very Low Very Low
Disease Progression 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we demonstrated that Smad2 and Smad3 were constitutively phosphorylated in activated HSCs, as reported previously (36), and that NIM811 suppressed the phosphorylation of Smad2 and Smad3 (Fig. 6).
NIM811 Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of Smad2 associated with cirrhosis
1) Confidence 0.01 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.

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