INT218671

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) aging (Timp1) extracellular region (Timp1)
proteinaceous extracellular matrix (Timp1) molecular_function (Mmp1a) cellular_component (Mmp1a)
Mmp1a (Rattus norvegicus)
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 5 78.24 Quite High
metalloproteinase 10 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 36 91.04 High High
Fibrosis 3 78.24 Quite High
Apoptosis 9 72.56 Quite High
Hepatitis C Virus Infection 10 57.60 Quite High
Cancer 2 24.60 Low Low
Hepatitis 2 5.00 Very Low Very Low Very Low
Disease Progression 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that treatment of the cells with NIM811 increased collagenase activity, accompanied by stimulation of the transcription and synthesis of MMP-1 and weak suppression of the expression of TIMP-1 (Figs 2 and 3).
MMP-1 Negative_regulation (suppression) of Gene_expression (expression) of TIMP-1
1) Confidence 0.02 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.60 Pain Relevance 0.06

General Comments

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