INT218689

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ppib) protein folding (Ppib) endoplasmic reticulum (Ppib)
Ppib (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 91.84 High High
Paracetamol 3 75.68 Quite High
fibrosis 15 60.32 Quite High
metalloproteinase 30 10.40 Low Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 30 98.52 Very High Very High Very High
Cirrhosis 108 76.80 Quite High
Necrosis 3 73.92 Quite High
Apoptosis 27 72.88 Quite High
Injury 3 61.60 Quite High
Fibrosis 9 60.32 Quite High
Disease Progression 6 54.04 Quite High
Toxicity 3 30.48 Quite Low
Hepatitis 6 19.36 Low Low
Renal Disease 3 11.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NIM811 is a four-substituted cyclosporine that does not bind to cyclophilin A and therefore lacks immunosuppressive activity; however, it retains the ability to bind other cyclophilins, such as cyclophilin B (13).
cyclophilin B Binding (bind) of
1) Confidence 0.04 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.87 Pain Relevance 0.08
Because NIM811 lacks the ability to bind to cyclophilin A (13), NIM811 exerts its pharmacological effects by binding to other cyclophilins, such as cyclophilin B or D.
cyclophilin B Binding (binding) of
2) Confidence 0.04 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.12 Pain Relevance 0
Notably, NIM811 exerts its antiviral effects via binding cyclophilin B, which is a functional regulator of HCV RNA polymerase (43).
cyclophilin B Binding (binding) of associated with hepatitis c virus infection
3) Confidence 0.03 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.34 Pain Relevance 0.08

General Comments

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