INT21869

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 16
Total Number 16
Disease Relevance 8.43
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Otc) cytoplasm (Otc)
Anatomy Link Frequency
liver 1
Otc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 11 99.96 Very High Very High Very High
rheumatoid arthritis 7 99.92 Very High Very High Very High
cINOD 70 99.54 Very High Very High Very High
Versed 4 99.22 Very High Very High Very High
anesthesia 19 99.08 Very High Very High Very High
Analgesic 4 97.84 Very High Very High Very High
Migraine 7 94.96 High High
imagery 5 94.88 High High
Arthritis 4 93.68 High High
Pain 4 91.12 High High
Disease Link Frequency Relevance Heat
Ornithine Transcarbamylase Deficiency 28 100.00 Very High Very High Very High
Osteoarthritis 11 99.96 Very High Very High Very High
Rheumatoid Arthritis 7 99.92 Very High Very High Very High
Stroke 6 99.92 Very High Very High Very High
Hyperammonemia 8 99.78 Very High Very High Very High
INFLAMMATION 7 99.44 Very High Very High Very High
Convulsion 2 99.16 Very High Very High Very High
Paresis 2 98.88 Very High Very High Very High
Heart Disease 2 98.08 Very High Very High Very High
Hemiplegia 4 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phenotype of ostensibly healthy women who are carriers for ornithine transcarbamylase deficiency.
Negative_regulation (deficiency) of ornithine transcarbamylase associated with ornithine transcarbamylase deficiency
1) Confidence 0.58 Published 1998 Journal Medicine (Baltimore) Section Title Doc Link 9854602 Disease Relevance 0.10 Pain Relevance 0
A 6-year-old female with disturbance of consciousness (JCS: 3 points) due to hyperammonemia caused by ornithine transcarbamylase deficiency is presented.
Negative_regulation (deficiency) of ornithine transcarbamylase associated with ornithine transcarbamylase deficiency and hyperammonemia
2) Confidence 0.56 Published 1996 Journal Masui Section Abstract Doc Link 8847794 Disease Relevance 0.52 Pain Relevance 0.24
[Abrupt onset and rapid deterioration in the course of congenital ornithine transcarbamylase deficiency: a case report].
Negative_regulation (deficiency) of transcarbamylase associated with ornithine transcarbamylase deficiency
3) Confidence 0.51 Published 1990 Journal Fukuoka Igaku Zasshi Section Title Doc Link 2210591 Disease Relevance 1.02 Pain Relevance 0.09
[Living related liver transplantation for patients with ornithine transcarbamylase deficiency].
Negative_regulation (deficiency) of transcarbamylase in liver associated with ornithine transcarbamylase deficiency and versed
4) Confidence 0.49 Published 1997 Journal Masui Section Title Doc Link 9223881 Disease Relevance 0.48 Pain Relevance 0.17
Acute hemiparesis as the presenting sign in a heterozygote for ornithine transcarbamylase deficiency.
Negative_regulation (deficiency) of transcarbamylase associated with ornithine transcarbamylase deficiency and paresis
5) Confidence 0.45 Published 1990 Journal Neuropediatrics Section Title Doc Link 2234317 Disease Relevance 1.31 Pain Relevance 0.14
[Ornithine transcarbamylase deficiency in adolescence and adulthood: first manifestation with life-threatening decompensation].
Negative_regulation (deficiency) of Ornithine transcarbamylase associated with ornithine transcarbamylase deficiency
6) Confidence 0.43 Published 2009 Journal Anaesthesist Section Title Doc Link 19468698 Disease Relevance 0.42 Pain Relevance 0.08
[An anesthetic experience with a patient with ornithine transcarbamylase deficiency].
Negative_regulation (deficiency) of ornithine transcarbamylase associated with ornithine transcarbamylase deficiency and anesthesia
7) Confidence 0.43 Published 1989 Journal Masui Section Title Doc Link 2709615 Disease Relevance 0.36 Pain Relevance 0.22
Ornithine transcarbamylase (OTC) deficiency is an X-linked disorder of urea synthesis.
Negative_regulation (deficiency) of OTC
8) Confidence 0.42 Published 1998 Journal Medicine (Baltimore) Section Abstract Doc Link 9854602 Disease Relevance 0.07 Pain Relevance 0
Ornithine transcarbamylase (OTC) deficiency is an X-linked disorder of urea synthesis.
Negative_regulation (deficiency) of Ornithine transcarbamylase
9) Confidence 0.42 Published 1998 Journal Medicine (Baltimore) Section Abstract Doc Link 9854602 Disease Relevance 0.07 Pain Relevance 0
Anesthetic management of patients with ornithine transcarbamylase deficiency.
Negative_regulation (deficiency) of ornithine transcarbamylase associated with ornithine transcarbamylase deficiency and versed
10) Confidence 0.42 Published 2006 Journal Paediatr Anaesth Section Title Doc Link 16490102 Disease Relevance 0.57 Pain Relevance 0.36
Nitric oxide synthesis in ornithine transcarbamylase deficiency: possible involvement of low no synthesis in clinical manifestations of urea cycle defect.
Negative_regulation (deficiency) of ornithine transcarbamylase associated with ornithine transcarbamylase deficiency
11) Confidence 0.41 Published 2004 Journal J. Pediatr. Section Title Doc Link 15289781 Disease Relevance 0.37 Pain Relevance 0.18
[Anesthetic management of a patient with ornithine transcarbamylase deficiency].
Negative_regulation (deficiency) of ornithine transcarbamylase associated with ornithine transcarbamylase deficiency
12) Confidence 0.41 Published 1996 Journal Masui Section Title Doc Link 8847794 Disease Relevance 0.61 Pain Relevance 0.37
This study was designed to define the phenotypic variability of OTC deficiency in ostensibly healthy carrier females and to compare them to noncarrier females from their own and other families.
Negative_regulation (deficiency) of OTC
13) Confidence 0.37 Published 1998 Journal Medicine (Baltimore) Section Abstract Doc Link 9854602 Disease Relevance 0.07 Pain Relevance 0
We describe a female heterozygote of ornithine transcarbamylase deficiency, who presented with convulsions and right sided hemiplegia.
Negative_regulation (deficiency) of transcarbamylase associated with ornithine transcarbamylase deficiency, convulsion and hemiplegia
14) Confidence 0.33 Published 1990 Journal Neuropediatrics Section Abstract Doc Link 2234317 Disease Relevance 1.27 Pain Relevance 0.14
Poisson technique indicated that, compared with those who used the sham intervention, participants who used GIR had a significant reduction in over-the-counter (OTC) medication use from baseline to month 4, prescribed analgesic use from baseline to month 4, and total medication (OTC, prescribed analgesic, and prescribed arthritis medication) use from baseline to month 2 and month 4.
Negative_regulation (reduction) of OTC associated with analgesic and arthritis
15) Confidence 0.12 Published 2010 Journal Pain Manag Nurs Section Abstract Doc Link 20207328 Disease Relevance 0.52 Pain Relevance 0.71
COX = cyclo-oxygenase; NSAID = nonsteroidal anti-inflammatory drug; OA = osteoarthritis; OTC = over-the-counter; PPI = proton pump inhibitor; RA = rheumatoid arthritis.


Negative_regulation (inhibitor) of OTC associated with inflammation, rheumatoid arthritis, cinod and osteoarthritis
16) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833978 Disease Relevance 0.66 Pain Relevance 0.98

General Comments

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