INT218691

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 3.00
Pain Relevance 0.38

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transport (Smad3) intracellular (Smad3) protein binding transcription factor activity (Smad3)
DNA binding (Smad3) protein complex (Smad3) cytoplasm (Smad3)
Smad3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 90 96.00 Very High Very High Very High
fibrosis 45 77.56 Quite High
Paracetamol 9 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 324 99.44 Very High Very High Very High
Apoptosis 81 99.36 Very High Very High Very High
Cancer 18 96.96 Very High Very High Very High
Fibrosis 27 77.56 Quite High
Hepatitis C Virus Infection 90 73.80 Quite High
Hepatitis 18 73.28 Quite High
Death 9 16.76 Low Low
Disease Progression 18 5.00 Very Low Very Low Very Low
Toxicity 9 5.00 Very Low Very Low Very Low
Necrosis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with NIM811 significantly suppressed the phosphorylation of Smad2 and Smad3 in a concentration-dependent manner; 0.5 mM NIM811 suppressed the phosphorylation of Smad2 and Smad3 by nearly 70 and 60% respectively (Fig. 6A and B).
Phosphorylation (phosphorylation) of Smad3
1) Confidence 0.28 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.32 Pain Relevance 0
For comparison, the ratios of phosphorylated Smad2 and Smad3 to nonphosphorylated Smad2 and Smad3, respectively, were calculated from the densitometric data.


Phosphorylation (phosphorylated) of Smad3
2) Confidence 0.28 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.12 Pain Relevance 0.07
Phosphorylation of mitogen-activated protein kinases (MAPKs), Smad2 and Smad3 was evaluated.
Phosphorylation (Phosphorylation) of Smad3
3) Confidence 0.28 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.90 Pain Relevance 0.13
Treatment with NIM811 significantly suppressed the phosphorylation of Smad2 and Smad3 in a concentration-dependent manner; 0.5 mM NIM811 suppressed the phosphorylation of Smad2 and Smad3 by nearly 70 and 60% respectively (Fig. 6A and B).
Phosphorylation (phosphorylation) of Smad3
4) Confidence 0.28 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.33 Pain Relevance 0
signal cascades through Smad2 and Smad3 strongly regulate the expression of the type I collagen gene (27), we evaluated the effects of NIM811 on the phosphorylation of Smad2 and Smad3.
Phosphorylation (phosphorylation) of Smad3
5) Confidence 0.28 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.32 Pain Relevance 0
For comparison, the ratios of phosphorylated Smad2 and Smad3 to nonphosphorylated Smad2 and Smad3, respectively, were calculated from the densitometric data.


Phosphorylation (nonphosphorylated) of Smad3
6) Confidence 0.28 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.12 Pain Relevance 0.08
In this study, we demonstrated that Smad2 and Smad3 were constitutively phosphorylated in activated HSCs, as reported previously (36), and that NIM811 suppressed the phosphorylation of Smad2 and Smad3 (Fig. 6).
Phosphorylation (phosphorylated) of Smad3 associated with cirrhosis
7) Confidence 0.28 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.18 Pain Relevance 0
In this study, we demonstrated that Smad2 and Smad3 were constitutively phosphorylated in activated HSCs, as reported previously (36), and that NIM811 suppressed the phosphorylation of Smad2 and Smad3 (Fig. 6).
Phosphorylation (phosphorylation) of Smad3 associated with cirrhosis
8) Confidence 0.12 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.17 Pain Relevance 0
signalling pathways, NIM811 enhanced the phosphorylation of JNK and p38, but not extracellular signal-regulated kinases 1 and 2, and suppressed the phosphorylation of Smad2 and Smad3, accompanied by increased Smad7 transcription and decreased TGF-?
Phosphorylation (phosphorylation) of Smad3
9) Confidence 0.12 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.53 Pain Relevance 0.09

General Comments

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