INT218698

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.01
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Anatomy Link Frequency
extracellular matrix 3
liver 2
spinal cord 2
connective tissue 1
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 271 100.00 Very High Very High Very High
antagonist 32 99.60 Very High Very High Very High
nMDA receptor antagonist 3 99.36 Very High Very High Very High
Kinase C 39 98.92 Very High Very High Very High
c fibre 105 98.12 Very High Very High Very High
Spinal cord 99 97.92 Very High Very High Very High
nMDA receptor 39 97.52 Very High Very High Very High
spinal dorsal horn 35 94.96 High High
qutenza 64 90.84 High High
Hyperalgesia 44 89.20 High High
Disease Link Frequency Relevance Heat
Li-fraumeni Syndrome 80 100.00 Very High Very High Very High
Hyperplasia 10 99.28 Very High Very High Very High
Apoptosis 53 98.98 Very High Very High Very High
Hyperglycemia 10 98.60 Very High Very High Very High
Neointima 12 95.92 Very High Very High Very High
Stress 16 95.36 Very High Very High Very High
Cirrhosis 36 92.04 High High
Renal Disease 3 90.64 High High
Hyperalgesia 52 89.20 High High
Neuropathic Pain 16 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alagebrium also inhibited the increase in formation of connective tissue and extracellular matrix (Fig. 4).
Negative_regulation (inhibited) of Positive_regulation (increase) of Fig in extracellular matrix
1) Confidence 0.20 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.82 Pain Relevance 0
The selectivity of action was tested using a TRPV1 antagonist (BCTC 500 nM) that reversed the RTX-induced increase in the frequency of sEPSCs (Fig.
Negative_regulation (reversed) of Positive_regulation (increase) of Fig associated with antagonist
2) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737142 Disease Relevance 0 Pain Relevance 0.56
M L-NAME, a NO synthase (NOS) inhibitor, 1 h before conditioning HFS of LT inhibited the induction of LTP (Fig. 3).
Negative_regulation (inhibited) of Positive_regulation (induction) of Fig associated with long-term potentiation
3) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.06 Pain Relevance 0.85
M 2-APB 1 h prior to HFS completely blocked the induction of hippocampal LTP (67.4 ± 10.2% of control, 30 min after HFS; n = 5) (Fig. 4B).
Negative_regulation (blocked) of Positive_regulation (induction) of Fig associated with long-term potentiation
4) Confidence 0.11 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0 Pain Relevance 0.64
Subsequent Western blot analysis of homogenized liver tissue confirmed that apoptosis was indeed inhibited by CORM-2, as evidenced by a reduction in the level of activation of effector caspase-3 (Fig. 3A and 3B, p < 0.05).
Negative_regulation (reduction) of Positive_regulation (activation) of Fig in liver associated with apoptosis
5) Confidence 0.09 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 1.07 Pain Relevance 0
Alagebrium also inhibited the increase in formation of connective tissue and extracellular matrix (Fig. 4).
Negative_regulation (inhibited) of in connective tissue Positive_regulation (increase) of Fig in extracellular matrix
6) Confidence 0.07 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 0.82 Pain Relevance 0
In summary, our data provide the first evidence that hyperglycemia and high glucose lead to phosphorylation/inactivation of tuberin and downregulation of DNA repair enzyme OGG1 via the redox-dependent activation of Akt (Fig. 9).
Negative_regulation (downregulation) of Positive_regulation (activation) of Fig associated with hyperglycemia
7) Confidence 0.05 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.60 Pain Relevance 0
Topical mibefradil completely prevented LTP induction (Fig. 2A; Table 1), suggesting that LFS of sciatic C-fibres is sufficient to activate T-type VDCCs in spinal cord, and that this contributes to LTP induction.
Negative_regulation (prevented) of Positive_regulation (induction) of Fig in spinal cord associated with c fibre, li-fraumeni syndrome, long-term potentiation and spinal cord
8) Confidence 0.04 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.71 Pain Relevance 1.04
As with citral, higher concentrations of the compounds also inhibited the currents they induced (Fig. 3D, E; Figs.
Negative_regulation (inhibited) of Positive_regulation (induced) of Fig
9) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.07
In this study, we demonstrated that NIM811 (0.125 mM), as well as cyclosporine, produced a concentration-dependent suppression of collagen accumulation (Fig. 1).
Negative_regulation (suppression) of Positive_regulation (accumulation) of Fig
10) Confidence 0.03 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.26 Pain Relevance 0
M) abolished induction of LTP by LFS in all animals tested (Fig. 2E; Table 1).
Negative_regulation (abolished) of Positive_regulation (induction) of Fig associated with li-fraumeni syndrome and long-term potentiation
11) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.96 Pain Relevance 1.70
M) prevented LTP induction (Fig 2F; Table 1).
Negative_regulation (prevented) of Positive_regulation (induction) of Fig associated with long-term potentiation
12) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.72 Pain Relevance 1.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox