INT218706

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.16
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP1) extracellular region (MMP1) proteinaceous extracellular matrix (MMP1)
signal transducer activity (Olr811)
Anatomy Link Frequency
liver 1
stellate cells 1
Olr811 (Rattus norvegicus)
MMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 25 100.00 Very High Very High Very High
cytokine 5 76.96 Quite High
metalloproteinase 50 75.08 Quite High
Paracetamol 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 180 100.00 Very High Very High Very High
Apoptosis 45 97.80 Very High Very High Very High
Fibrosis 15 96.96 Very High Very High Very High
Hepatitis 10 95.40 Very High Very High Very High
Hepatitis C Virus Infection 50 94.64 High High
Cancer 10 71.28 Quite High
Injury 5 46.72 Quite Low
Disease Progression 10 39.16 Quite Low
Toxicity 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results indicate that NIM811 has therapeutic potential for liver fibrosis through suppression of collagen production and enhancement of collagenase activity.
NIM811 Positive_regulation (enhancement) of collagenase in liver associated with fibrosis and cirrhosis
1) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.63 Pain Relevance 0.09
We demonstrated that NIM811 not only suppressed proliferation and collagen production but also enhanced collagenase activity in HSCs, indicating that NIM811 is a potential candidate for anti-fibrosis therapy.
NIM811 Positive_regulation (enhanced) of collagenase associated with fibrosis and cirrhosis
2) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.74 Pain Relevance 0.09
These findings demonstrate that NIM811 not only suppresses collagen production and proliferation but also increases collagenase activity.
NIM811 Positive_regulation (increases) of collagenase
3) Confidence 0.00 Published 2007 Journal Liver International Section Abstract Doc Link PMC2156109 Disease Relevance 0.33 Pain Relevance 0.06
To explore the mechanism by which NIM811 suppresses collagen production and cell proliferation, and enhances collagenase activity, we examined the effects of NIM811 on intra-cellular signalling cascades, such as MAPK cascades, which play important roles in collagen production and cell proliferation in HSCs (33).
NIM811 Positive_regulation (enhances) of collagenase associated with cirrhosis
4) Confidence 0.00 Published 2007 Journal Liver International Section Body Doc Link PMC2156109 Disease Relevance 0.61 Pain Relevance 0.09
NIM811, a nonimmunosuppressive cyclosporine analogue, suppresses collagen production and enhances collagenase activity in hepatic stellate cells

Background/Aims

NIM811 Positive_regulation (enhances) of collagenase in stellate cells associated with cirrhosis
5) Confidence 0.00 Published 2007 Journal Liver International Section Title Doc Link PMC2156109 Disease Relevance 0.85 Pain Relevance 0.12

General Comments

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