INT218757

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Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 5.51
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pnp) extracellular region (Pnp) transferase activity, transferring glycosyl groups (Pnp)
cytoskeleton (Pnp) nucleus (Pnp) intracellular (Pnp)
Pnp (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 87.04 High High
anesthesia 23 45.68 Quite Low
ketamine 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 160 100.00 Very High Very High Very High
Ebola Virus Infection 30 99.52 Very High Very High Very High
Severe Combined Immunodeficiency 144 98.48 Very High Very High Very High
Sprains And Strains 124 97.24 Very High Very High Very High
Infection 136 94.60 High High
Influenza In Birds 10 89.72 High High
Death 62 89.08 High High
Disease 62 89.04 High High
Lymphopenia 12 87.44 High High
Weight Loss 40 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasmid DNA without an insert is often used as a control; although we used it initially, we later prepared a construct expressing the NP gene of influenza B/AA as a specificity control.
Regulation (control) of NP gene associated with influenza virus infection
1) Confidence 0.15 Published 2002 Journal Emerging Infectious Diseases Section Body Doc Link PMC2732511 Disease Relevance 0.55 Pain Relevance 0
Based on previous reports with mouse and guinea pig-adapted EBOV [18,33,34], we predict changes in VP24, VP35, NP, and L are likely to be important for enhanced virulence of the 'scid-adapted' MARV.
Regulation (changes) of NP associated with ebola virus infection and severe combined immunodeficiency
2) Confidence 0.06 Published 2007 Journal Virol J Section Body Doc Link PMC2164958 Disease Relevance 0.74 Pain Relevance 0.04
In the second portion of this experiment, we tested the efficacy of a combination of four anti-MARV PMOs targeting VP24, VP35, NP and L (Figure 9).
Regulation (targeting) of NP
3) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC2164958 Disease Relevance 1.65 Pain Relevance 0
While we continued to evaluate the protective efficacy of NP and M2 in the mouse model, we extended our investigation into the ferret model in this study.
Regulation (efficacy) of NP
4) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 1.20 Pain Relevance 0
Here, we investigate the relative efficacy of NP and M2 compared to HA in protecting against HPAI H5N1 virus.
Spec (investigate) Regulation (efficacy) of NP
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2843722 Disease Relevance 0.52 Pain Relevance 0
For both NP and NP+M2 immunized groups, significant anti-NP humoral responses were observed after the rAd boost (p<0.0001) (Figure 4B, middle panel) compared to controls.
Regulation (responses) of NP
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.23 Pain Relevance 0
Briefly, mice (10 animals for each group of HA alone, HA+NP, and HA+NP+M2; and 5 animals for the NP alone and vector control) were immunized three times with a total of 15 µg plasmid DNA in 100 µl of PBS (pH 7.4) intramuscularly at 0, 3, and 6 weeks.
Regulation (control) of NP
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.13 Pain Relevance 0
However, we find that the protective efficacy of NP and M2 diminishes as the virulence and dose of the challenge virus are increased.
Regulation (efficacy) of NP
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2843722 Disease Relevance 0.49 Pain Relevance 0

General Comments

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