INT218776

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ccdc80) proteinaceous extracellular matrix (Ccdc80) extracellular matrix organization (Ccdc80)
Anatomy Link Frequency
tail 1
Ccdc80 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 66 99.28 Very High Very High Very High
agonist 42 95.84 Very High Very High Very High
Antinociceptive 1 94.80 High High
Multiple sclerosis 1 86.64 High High
Arthritis 2 85.84 High High
nociceptor 46 65.68 Quite High
depression 83 63.76 Quite High
Cannabinoid 16 61.72 Quite High
Endocannabinoid 62 58.76 Quite High
fluoxetine 10 55.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 36 94.04 High High
Systemic Lupus Erythematosus 1 87.08 High High
Demyelinating Disease 1 86.64 High High
Arthritis 2 85.84 High High
Cancer 4 85.12 High High
Airway Obstruction 1 77.40 Quite High
Cough 3 76.60 Quite High
Dyspnea 1 76.32 Quite High
Sleep Disorders 1 75.48 Quite High
Depression 92 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB 597), a potent and systemically active inhibitor of FAAH (the enzyme responsible for anandamide degradation) was recently shown to directly gate TRPA1 and is being pursued as an antinociceptive drug [150].


Negative_regulation (inhibitor) of URB associated with antinociceptive
1) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.80 Pain Relevance 0.39
According to this hypothesis, it has been reported that URB597, a potent FAAH inhibitor [63], elicits an antidepressant-like response in the mouse tail suspension test and in the rat forced swimming test.
Negative_regulation (inhibitor) of URB597 in tail associated with antidepressant
2) Confidence 0.01 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.17 Pain Relevance 0.60

General Comments

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