INT218778

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cfp)
Anatomy Link Frequency
PFC 2
Cfp (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 10 99.98 Very High Very High Very High
Hippocampus 11 97.00 Very High Very High Very High
Cannabinoid 13 96.04 Very High Very High Very High
Endocannabinoid 62 91.04 High High
antidepressant 66 79.64 Quite High
depression 82 66.56 Quite High
amygdala 1 26.48 Quite Low
monoamine 11 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Cannabinoid receptor 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 15 72.00 Quite High
Depression 91 66.56 Quite High
Neurodegenerative Disease 15 34.32 Quite Low
Targeted Disruption 13 29.60 Quite Low
Manic Depressive Disorder 10 5.00 Very Low Very Low Very Low
Suicidal Behaviour 8 5.00 Very Low Very Low Very Low
Affective Disorder 6 5.00 Very Low Very Low Very Low
Psychosis 5 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, it has been reported that chronic fluoxetine causes an up-regulation of CB1 receptors in the Prefrontal cortex (PFC), [78,79], chronic DMI up-regulates CB1 receptors in the hypothalamus and hippocampus [78,79], tranylcypromine (a MAOI) decreases the levels of anandamide in the PFC, hippocampus and hypothalamus, and increases CB1 receptor binding in PFC and the hippocampus, but not in the hypothalamus [78,79].
Positive_regulation (causes) of Regulation (regulation) of PFC in PFC associated with hippocampus and fluoxetine
1) Confidence 0.07 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.31 Pain Relevance 0.92

General Comments

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