INT218779

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.89
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cfp)
Anatomy Link Frequency
brain 1
PFC 1
white matter 1
Cfp (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 43 99.92 Very High Very High Very High
fluoxetine 10 96.16 Very High Very High Very High
Locus ceruleus 5 91.32 High High
Cannabinoid 13 88.40 High High
Endocannabinoid 62 83.84 Quite High
agonist 31 78.56 Quite High
antidepressant 66 72.00 Quite High
Neurotransmitter 26 66.48 Quite High
depression 86 58.92 Quite High
amygdala 1 39.76 Quite Low
Disease Link Frequency Relevance Heat
Poisoning 434 100.00 Very High Very High Very High
Schizophrenia 80 89.00 High High
Stress 36 64.36 Quite High
Depression 95 58.92 Quite High
Congenital Anomalies 12 57.52 Quite High
Ciguatera Poisoning 108 50.00 Quite Low
Targeted Disruption 17 45.36 Quite Low
Neurodegenerative Disease 15 26.68 Quite Low
Toxicity 64 5.00 Very Low Very Low Very Low
Death 32 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it should be noted that, the antipsychotics alone did not decrease DA levels in PFC.
Neg (not) Negative_regulation (decrease) of PFC
1) Confidence 0.14 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.15 Pain Relevance 0.04
In a context where the importance of CFP may be recognized world-wide, and considering the possible increase of CFP cases in traditionally non-endemic areas in Europe and elsewhere, it becomes clear that CFP risk analysis has to be improved to reduce CFP impact.

2.

Negative_regulation (reduce) of CFP associated with poisoning
2) Confidence 0.12 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.97 Pain Relevance 0
Understanding the distribution of CFP toxin-producing benthic dinoflagellates and evaluating CFP toxins in fish and microalgae should allow a better prediction of CFP risk.
Negative_regulation (prediction) of CFP associated with poisoning
3) Confidence 0.11 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 1.09 Pain Relevance 0
Although it is now unclear how white matter damage impairs the social interaction in CPZ-treated mice, some clues may be drawn from the following findings of the present study: first, HAL did not improve the performance of CPZ-treated mice in social interaction test (Figure 3A) whereas it mitigated the CPZ-induced MBP decrease in PFC (Figure 5); second, the myelin sheath loss in CPZ?
Negative_regulation (decrease) of PFC in white matter
4) Confidence 0.10 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.06 Pain Relevance 0.03
Both CLZ and HAL ameliorated the decrease in the amount of MBP in PFC of mice exposed to CPZ (Figure 5) and the same drugs also blocked the CPZ-induced high levels of DA in the same brain region (Figure 4).
Negative_regulation (decrease) of PFC in brain
5) Confidence 0.10 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.05 Pain Relevance 0.12
Furthermore, all antipsychotics tested in this study completely blocked the CPZ-induced PPI deficits (Figure 1) and attenuated the CPZ-induced high levels of DA in PFC (Figure 4).
Negative_regulation (attenuated) of PFC
6) Confidence 0.10 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.40 Pain Relevance 0.03
On the contrary, it has been reported that chronic fluoxetine causes an up-regulation of CB1 receptors in the Prefrontal cortex (PFC), [78,79], chronic DMI up-regulates CB1 receptors in the hypothalamus and hippocampus [78,79], tranylcypromine (a MAOI) decreases the levels of anandamide in the PFC, hippocampus and hypothalamus, and increases CB1 receptor binding in PFC and the hippocampus, but not in the hypothalamus [78,79].
Negative_regulation (decreases) of PFC in PFC associated with hippocampus and fluoxetine
7) Confidence 0.08 Published 2007 Journal Clin Pract Epidemiol Ment Health Section Body Doc Link PMC2169225 Disease Relevance 0.17 Pain Relevance 0.97
2AAR-YFP/CFP activation causes a conformational change leading to the reduction of the FRET efficiency between CFP and YFP [19].
Negative_regulation (reduction) of CFP
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855346 Disease Relevance 0 Pain Relevance 0

General Comments

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