INT218805

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) plasma membrane (Gria2)
protein complex (Gria2)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 18 100.00 Very High Very High Very High
Pain 11 99.44 Very High Very High Very High
Glutamate 3 92.24 High High
Lasting pain 6 88.28 High High
Hippocampus 19 84.88 Quite High
Neuropathic pain 4 74.84 Quite High
Inflammation 9 74.04 Quite High
Spinal cord 10 66.12 Quite High
spinal dorsal horn 7 63.24 Quite High
depression 41 56.40 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 91 99.48 Very High Very High Very High
Pain 10 88.28 High High
Neuropathic Pain 4 74.84 Quite High
INFLAMMATION 9 74.04 Quite High
Motor Neuron Diseases 1 69.20 Quite High
Neurodegenerative Disease 1 67.64 Quite High
Nociception 29 60.28 Quite High
Disease 1 59.00 Quite High
Depression 41 56.40 Quite High
Anxiety Disorder 28 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation of GluR2 subunit at Serine880 by PKC may lead to disrupt the interaction between GluR2 and GRIP and follow by GluR2 internalization.
Negative_regulation (disrupt) of Phosphorylation (phosphorylation) of GluR2 associated with kinase c
1) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.62 Pain Relevance 0.56
Third, the phosphorylation of AMPA receptor may be altered in neurabin KO mice.
Negative_regulation (altered) of Phosphorylation (phosphorylation) of AMPA associated with targeted disruption
2) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.89 Pain Relevance 0.17

General Comments

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