INT218810

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.06
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Ppp1r9a)
Ppp1r9a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 60 99.00 Very High Very High Very High
long-term potentiation 220 98.00 Very High Very High Very High
depression 156 95.48 Very High Very High Very High
Hippocampus 48 90.24 High High
addiction 8 74.04 Quite High
Pyramidal cell 24 5.00 Very Low Very Low Very Low
tail-flick 16 5.00 Very Low Very Low Very Low
amygdala 12 5.00 Very Low Very Low Very Low
cocaine 4 5.00 Very Low Very Low Very Low
Acute pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 360 100.00 Very High Very High Very High
Depression 156 95.48 Very High Very High Very High
Anxiety Disorder 112 50.00 Quite Low
Shock 28 5.00 Very Low Very Low Very Low
Nociception 12 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Hypesthesia 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the reduction in Ser 845 phosphorylation seen in the neurabin KO may decrease the pool of “primed” receptors, and hence inhibit LTP.
Phosphorylation (phosphorylation) of neurabin KO associated with targeted disruption and long-term potentiation
1) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.04 Pain Relevance 0.62
Phosphorylation of NMDA receptor is critical for the receptor activity and PP1, a neurabin-binding protein, is known to regulate protein phosphorylation [14], [32].
Phosphorylation (phosphorylation) of neurabin-binding protein associated with nmda receptor
2) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.78 Pain Relevance 0.42
The increased AMPA receptor-mediated synaptic responses may reflect the altered expression or phosphorylation of AMPA receptors in neurabin KO mice [20].
Phosphorylation (phosphorylation) of neurabin KO associated with targeted disruption
3) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.58 Pain Relevance 0.08
First, the reduced phosphorylation of GluR1p845 in the neurabin KO may affect activity-dependent AMPA receptor contribution to LTP.
Phosphorylation (phosphorylation) of neurabin KO associated with targeted disruption and long-term potentiation
4) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.66 Pain Relevance 0.23

General Comments

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