INT218814

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.95
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
neurons 8
hippocampus 6
pyramidal neurons 2
cortex 2
ventral 2
Car1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 375 100.00 Very High Very High Very High
Hippocampus 231 100.00 Very High Very High Very High
Pyramidal cell 109 100.00 Very High Very High Very High
amygdala 14 99.04 Very High Very High Very High
ischemia 5 96.12 Very High Very High Very High
Anterior cingulate cortex 79 94.84 High High
Acute pain 2 83.88 Quite High
depression 118 73.04 Quite High
Neurotransmitter 9 71.84 Quite High
Neuronal excitability 17 68.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 354 100.00 Very High Very High Very High
Cv Unclassified Under Development 3 96.12 Very High Very High Very High
Congenital Anomalies 10 93.80 High High
Anxiety Disorder 169 93.44 High High
Brain Hemorrhage 2 92.08 High High
Shock 114 90.44 High High
Hypesthesia 2 89.84 High High
Body Weight 4 85.04 High High
Pain 20 83.88 Quite High
Depression 118 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that deletion of GluR2 in the CA1 region of the hippocampus impairs the formation of spatial memory.
Negative_regulation (deletion) of Gene_expression (region) of CA1 in hippocampus associated with hippocampus
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.11 Pain Relevance 0.14
This suggests that GluR2 deletion in CA1 selectively impairs NMDAR-dependent learning.
Negative_regulation (impairs) of Gene_expression (deletion) of CA1
2) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0 Pain Relevance 0.18
Mutant mice were engineered with a conditional genetic deletion of GluR2 in the CA1 region of the hippocampus (GluR2-cKO mice).
Negative_regulation (deletion) of Gene_expression (region) of CA1 in hippocampus associated with hippocampus
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2947514 Disease Relevance 0.06 Pain Relevance 0.26
+2.0 mm ventral to dura), the hippocampal CA1 region (AP?
Negative_regulation (hippocampal) of Gene_expression (region) of CA1 in ventral
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.09 Pain Relevance 0
Thus, basal NMDAR-mediated, but not AMPAR-mediated, synaptic responses are impaired in CA1 pyramidal neurons in the absence of Neto1.
Negative_regulation (impaired) of Gene_expression (pyramidal neurons) of CA1 in pyramidal neurons associated with pyramidal cell
5) Confidence 0.22 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.09 Pain Relevance 0.08
We first show that within the SC/CA1 pathway, Cdk5 KO mice displayed altered LTP-inducing TBS topography.
Negative_regulation (displayed) of Gene_expression (pathway) of CA1 associated with targeted disruption
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.49 Pain Relevance 0.14
Consistently, we found increased AMPA receptor-mediated synaptic transmission and reduced LTP in hippocampal CA1 neurons.
Negative_regulation (reduced) of Gene_expression (neurons) of CA1 in neurons associated with long-term potentiation
7) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.22 Pain Relevance 0.49
Consistently, we found increased AMPA receptor-mediated synaptic transmission and reduced LTP in hippocampal CA1 neurons.
Negative_regulation (hippocampal) of Gene_expression (neurons) of CA1 in neurons associated with long-term potentiation
8) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.22 Pain Relevance 0.49
To induce LTP in hippocampal CA1 neurons, the pairing protocol involving holding CA1 neurons at +30 mV paired with 80 pulses of presynaptic stimulation at 2 Hz was used (Figure 3A).
Negative_regulation (hippocampal) of Gene_expression (neurons) of CA1 in neurons associated with long-term potentiation
9) Confidence 0.20 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.37 Pain Relevance 0.57
In CA1 region of the hippocampus, protein kinase M?
Negative_regulation (hippocampus) of Gene_expression (region) of CA1 in hippocampus associated with hippocampus
10) Confidence 0.17 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.73
Following in situ for SNCA, we observed approximately 60% knockdown in SNCA expression in the right CA1 and cortex compared to the uninjected left side (Figure 3) which replicated our previous experiments.
Negative_regulation (knockdown) of Gene_expression (expression) of CA1 in cortex
11) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0 Pain Relevance 0.03
We were able to use this approach to show that reducing TRPM7 currents in CA1 neurons of the rat provides substantial protection against the loss of CA1 neurons in a model of global ischemia [5,7].
Negative_regulation (reducing) of Gene_expression (neurons) of CA1 in neurons associated with ischemia
12) Confidence 0.06 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0.30 Pain Relevance 0.13

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