INT21882

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Context Info
Confidence 0.45
First Reported 1982
Last Reported 2002
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 0.28
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Dbi) transport (Dbi) mitochondrion (Dbi)
extracellular space (Dbi) plasma membrane (Dbi) nucleus (Dbi)
Anatomy Link Frequency
thyroid 3
lymphocytes 2
lung 1
Dbi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 2 100.00 Very High Very High Very High
Calcium channel 1 99.76 Very High Very High Very High
sodium channel 1 98.68 Very High Very High Very High
alcohol 1 98.10 Very High Very High Very High
opiate 2 75.68 Quite High
acular 2 75.00 Quite High
cINOD 1 48.44 Quite Low
Analgesic 3 43.72 Quite Low
narcan 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 2 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 1 82.68 Quite High
INFLAMMATION 1 47.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol-stimulated beta-EP secretion required extracellular calcium and was blocked by a calcium channel blocker; a sodium channel blocker did not affect ethanol-stimulated secretion.
Negative_regulation (blocked) of Localization (secretion) of beta-EP associated with calcium channel and sodium channel
1) Confidence 0.45 Published 1990 Journal Life Sci. Section Abstract Doc Link 2215079 Disease Relevance 0 Pain Relevance 0.18
In conclusion, repeated administration of KT showed no impairment of Ep production and release in response to reduced hematocrit, suggesting that in this instance, prostaglandin inhibition plays a minimal role in Ep production or release.
Negative_regulation (impairment) of Localization (release) of Ep
2) Confidence 0.42 Published 1994 Journal Int J Artif Organs Section Abstract Doc Link 7759142 Disease Relevance 0.08 Pain Relevance 0.07
BACKGROUND: We have previously shown that alcohol suppresses the natural killer (NK) cell activity of splenic lymphocytes partly by reducing the secretion of opioid peptide beta-endorphin (beta-EP) and its positive influence on NK-cell cytolytic activity in rats.
Negative_regulation (reducing) of Localization (secretion) of beta-EP in lymphocytes associated with opioid and alcohol
3) Confidence 0.30 Published 2002 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 12436062 Disease Relevance 0 Pain Relevance 0.15
Ectopic secretion of ACTH and beta EP by lung and thyroid neoplasms may thus represent the loss of a system(s) normally responsible for processing the precursor beyond ACTH and beta EP.
Spec (may) Negative_regulation (represent) of Localization (secretion) of EP in thyroid associated with thyroid neoplasm
4) Confidence 0.11 Published 1982 Journal Endocrinology Section Abstract Doc Link 6291910 Disease Relevance 0.10 Pain Relevance 0.08
Ectopic secretion of ACTH and beta EP by lung and thyroid neoplasms may thus represent the loss of a system(s) normally responsible for processing the precursor beyond ACTH and beta EP.
Spec (may) Negative_regulation (represent) of in lung Localization (secretion) of EP in thyroid associated with thyroid neoplasm
5) Confidence 0.04 Published 1982 Journal Endocrinology Section Abstract Doc Link 6291910 Disease Relevance 0.10 Pain Relevance 0.08

General Comments

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